Showing papers in "The Lancet in 1989"

TL;DR: Measurements that promote prenatal and postnatal growth may reduce deaths from ischaemic heart disease and may be especially important in boys who weigh below 7.5 pounds (3.4 kg) at birth.

TL;DR: Evidence from this study and other trials suggest that consideration should be given to a national programme of FOB screening to reduce CRC mortality in the general population.

TL;DR: A modest intake of fatty fish (two or three portions per week) may reduce mortality in men who have recovered from MI.

TL;DR: The effect of psychosocial intervention on time of survival of 86 patients with metastatic breast cancer was studied prospectively and survival plots indicated that divergence in survival began at 20 months after entry, or 8 months after intervention ended.

TL;DR: Results indicate that the dilator action of endothelium-derived NO contributes to the control of basal and stimulated regional blood flow in man.

TL;DR: The incidence of thromboembolic complications and vascular mortality were significantly lower in the warfarin group than in the aspirin and placebo groups, which did not differ significantly.

TL;DR: Computer modelling and histological findings showed that site of tearing was influenced by variation in the mechanical strength of cap tissue due to focal accumulation of foam cells, and the distribution of circumferential tensile stress across the intima was radically altered by atherosclerotic plaques.

TL;DR: To test the hypothesis that the absence of HBeAg production may be due to a change in the nucleotide sequence of the pre-core region of the genome, 18 Greek and 3 non-Greek patients positive for HB surface antigen underwent direct sequencing of HBV-DNA amplified from sera.

TL;DR: In rheumatoid arthritis, TNF alpha may be the main inducer of IL-1, and anti-TNF alpha agents may be useful in treatment.

TL;DR: Findings contradict the long-held notion of basement membrane thickening in asthma and indicate that the subepithelial fibrosis is a result of fibroblast activation rather than bronchial epithelial cell dysfunction.

TL;DR: It is proposed that the accumulation of mitochondrial mutations and the subsequent cytoplasmic segregation of these mutations during life is an important contributor both to the ageing process and to several human degenerative diseases.

TL;DR: The frequency of new primary cancers was studied in 1846 postmenopausal patients included in a randomised trial of tamoxifen as an adjunct to primary surgery for early breast cancer and the increase in endometrial cancers was most pronounced in those treated for over 2 years.

TL;DR: The frequency of hepatitis C virus infection in Spain was assessed by means of a recombinant-based immunoassay for serum anti-HCV antibodies and only 8% of homosexual men infected with human immunodeficiency virus and 6% of female contacts of drug abusers were positive.

TL;DR: It is suggested that GH, in a conventional replacement dose, has several potentially beneficial effects in GH-deficient adults and therefore encourage future long-term trials.

TL;DR: FK 506 was given for immunosuppression in 14 liver recipients and 2 of the 14 Liver recipients were given cadaveric kidneys, either from the same donor or from a different donor, and a third was given a pancreas as well as a kidney from the liver donor.

TL;DR: The Canadian American Ticlopidine Study (CATS) as discussed by the authors is a randomized, double-blind, placebo-controlled trial to assess the effect of ticloopidine (250 mg twice daily) in reducing the rate of subsequent occurrence of stroke, myocardial infarction, or vascular death in patients who have had a recent thromboembolic stroke.

TL;DR: In this paper, 21 malades atteints de deficience en hormone de croissance sont traites pendant 4 mois par l'hormone ou par placebo.

TL;DR: The rapid haematological recovery made possible by this approach promises to increase the therapeutic index of high-dose chemoradiotherapy regimens and to widen their role as treatment for chemoradiosensitive tumours.

TL;DR: Glutathione enhances immune function, glutathione deficiency may contribute to the progressive immune dysfunction of HIV infection, and there was no correlation between ELF and plasma concentrations of total or reduced glutATHione.

TL;DR: A substantial fall in mitochondrial oxidative capacity in ageing muscle is suggested, which may contribute to reduced exercise capacity in elderly people and contribute to the ageing process in other organs.

TL;DR: The results indicate that HCV infection may have a role in the pathogenesis of hepatocellular carcinoma, even in patients with chronic liver disease apparently related to other agents such as alcohol, and that this recently identified hepatitis virus may be found in a large proportion of patients with cryptogenic cirrhosis.

TL;DR: A 5-stage classification of duodenal polyposis on a 5-grade scale (stages 0-IV), based on polyp number, size, histology, and severity of dysplasia, showed that 11 patients had stage IV disease.

TL;DR: In this article, a prospective study was carried out in 422 men who had acquired a sexually transmitted disease (STD) from a group of prostitutes with a prevalence of HIV-1 infection of 85%.

TL;DR: In a survey of eighty-eight county districts within England and Wales, rates of Alzheimer's disease in people under the age of 70 years were estimated from the records of the computerised tomographic scanning units that served these districts, finding no evidence of a relation between other causes of dementia, or epilepsy, and aluminium concentrations in water.

TL;DR: Data indicate that, in Italy, HCV is an important factor associated with hepatocellular carcinoma and non-A, non-B chronic hepatitis.

TL;DR: Blood samples taken in 1974 in Washington County, Maryland, from 25 620 volunteers were used to investigate the relation of serum 25-hydroxyvitamin D (25-OHD) with subsequent risk of getting colon cancer, and results are consistent with a protective effect of serum 20 ng/ml on colon cancer.

TL;DR: In acute pancreatitis, APACHE-II may facilitate rapid selection of patients for intensive therapy or clinical trials, improve comparison between groups of patients, and indicate that a pancreatic collection is probable.