Joseph Boulanger

TL;DR: In vitro analysis of active phosphate transport in ileum segments isolated from wild-type or Npt2b(-/-) mice demonstrated that NPT2b contributes to >90% of total active phosphate absorption, confirming a major role of this transporter in phosphate regulation.

TL;DR: It is confirmed that jck mice develop progressive biochemical changes in CKD‐MBD and suggested that repression of the Wnt/β‐catenin pathway is involved in the pathogenesis of renal osteodystrophy.

TL;DR: Targeting Npt2b in addition to using dietary phosphorus binders may be a therapeutic approach to modulate serum phosphate in CKD, and targeting sevelamer carbonate further reduced serum phosphate levels.

TL;DR: Increased levels of miR-21 in human Alport kidney samples showed a correlation with kidney disease severity measured by proteinuria, biomarkers of kidney function, and kidney histopathology scores, and support mi R-21 as a viable therapeutic target for the treatment of Alport syndrome.

TL;DR: Histomorphometric analysis indicated that 1D11 administration increased bone volume and suppressed the elevated bone turnover in a dose‐dependent manner, and data suggest that elevated TGF‐β may contribute to the pathogenesis of high‐turnover disease partially through inhibition of β‐catenin signaling.