Joseph J. Morrissey

TL;DR: The present hepatocyte culture system exhibits a responsiveness to drug inducers that is qualitatively and quantitatively comparable with that observed in vivo, and should prove valuable for more detailed investigations of the molecular and mechanistic basis of the response to PB and its modulation by endogenous hormones.

TL;DR: Rat hepatic cytochrome P-450 form RLM2 is a testosterone 15 alpha-hydroxylase reported to be male-specific on the basis of purification studies and its adult male- specific expression is imprinted (programmed) in response to neonatal testosterone exposure.

TL;DR: These studies demonstrate that these female-predominant hepatic P-450 enzymes are regulated by different mechanisms, and that both are under hormonal regulatory controls distinct from those that govern expression of the female-specific hepatic enzymes.

TL;DR: Northern blot analysis revealed that T4, but not ACTH or human CG, can act in concert with GH to effect a more complete suppression of hepatic P-450 IIIA2 mRNA and protein in hypophysectomized rats, suggesting that other pituitary-dependent factors contribute to the suppression observed in the intact rats.

TL;DR: The results establish that hepatic P-450 reductase is subject to hormonal controls that are distinct from those governing cytochrome P- 450 expression and further demonstrate the complexity of endocrine control of hepatic steroid hormone metabolism.