J
Joseph K. Yu
Researcher at Johns Hopkins University
Publications - 6
Citations - 101
Joseph K. Yu is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Internal medicine & Heart failure. The author has an hindex of 2, co-authored 4 publications receiving 55 citations. Previous affiliations of Joseph K. Yu include Johns Hopkins University School of Medicine.
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Journal ArticleDOI
Early somatic mosaicism is a rare cause of long-QT syndrome.
James R. Priest,Charles Gawad,Kristopher M. Kahlig,Joseph K. Yu,Thomas O'Hara,Patrick M. Boyle,Sridharan Rajamani,Michael J. Clark,Sarah Garcia,Scott R. Ceresnak,Jason B. Harris,Sean Michael Boyle,Frederick E. Dewey,Lindsey Malloy-Walton,Kyla Dunn,Megan E. Grove,Marco V Perez,Norma F. Neff,Richard Chen,Katsuhide Maeda,Anne M. Dubin,Luiz Belardinelli,John A. West,Christian Antolik,Daniela Macaya,Thomas Quertermous,Natalia A. Trayanova,Stephen R. Quake,Euan A. Ashley +28 more
TL;DR: Cardiac mosaicism is established as a causal mechanism for LQTS and methods by which the general phenomenon can be detected through single-cell analysis and next-generation sequencing are presented.
Journal ArticleDOI
A comprehensive, multiscale framework for evaluation of arrhythmias arising from cell therapy in the whole post-myocardial infarcted heart
Joseph K. Yu,William H. Franceschi,Qinwen Huang,Farhad Pashakhanloo,Patrick M. Boyle,Natalia A. Trayanova +5 more
TL;DR: A comprehensive framework for computational modeling of direct remuscularization approaches to cell therapy integrates realistic representations of cell delivery and transdifferentiation therapy modalities as well as representation of spatial distributions of engrafted cells, enabling simulation of clinical therapy and the prediction of emergent electrophysiological behavior and arrhythmogenensis.
Journal ArticleDOI
Computational modeling of aberrant electrical activity following remuscularization with intramyocardially injected pluripotent stem cell-derived cardiomyocytes.
Joseph K. Yu,Joseph K. Yu,Jialiu A Liang,Seth H. Weinberg,Seth H. Weinberg,Natalia A. Trayanova,Natalia A. Trayanova +6 more
TL;DR: In this paper, the authors investigated the origin of arrhythmias arising from immature stem cell-derived cardiomyocytes (PSC-CMs) in nascent myocardial grafts.
Journal ArticleDOI
Assessment of arrhythmia mechanism and burden of the infarcted ventricles following remuscularization with pluripotent stem cell-derived cardiomyocyte patches using patient-derived models.
Joseph K. Yu,Jialiu A Liang,William H. Franceschi,Qinwen Huang,Farhad Pashakhanloo,Eric Sung,Eric Sung,Patrick M. Boyle,Natalia A. Trayanova,Natalia A. Trayanova +9 more
TL;DR: In this article, the authors investigated two possible mechanisms of arrhythmogenesis-focal vs reentrant-arising from direct remuscularization with PSC-CMs in two personalized, human ventricular computer models of post-MI.
Journal ArticleDOI
Biological substrate modification suppresses ventricular arrhythmias in a porcine model of chronic ischaemic cardiomyopathy.
James Dawkins,Ashkan Ehdaie,Russell G. Rogers,Daniel Soetkamp,Jackelyn Valle,Kevin Holm,Lizbeth Sanchez,Ileana Tremmel,Asma Nawaz,Michael Shehata,Xunzhang Wang,Adityo Prakosa,Joseph K. Yu,Jennifer E. Van Eyk,Natalia A. Trayanova,Eduardo Marbán,Eugenio Cingolani +16 more
TL;DR: Biological substrate modification by exosome injection may be worth developing as a non-destructive alternative to conventional ablation for the prevention of recurrent ventricular tachyarrhythmias in ischaemic cardiomyopathy.