J
Joseph Kessler
Researcher at United States Military Academy
Publications - 29
Citations - 1841
Joseph Kessler is an academic researcher from United States Military Academy. The author has contributed to research in topics: Pyrrolidine & Antibody. The author has an hindex of 23, co-authored 29 publications receiving 1798 citations.
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Journal ArticleDOI
Neutralization of divergent human immunodeficiency virus type 1 variants and primary isolates by IAM-41-2F5, an anti-gp41 human monoclonal antibody.
Anthony J. Conley,Joseph Kessler,Lynn J. Boots,Jwu-Sheng Tung,Beth A. Arnold,Paul M. Keller,Alan R. Shaw,Emilio A. Emini +7 more
TL;DR: The antiviral characteristics of monoclonal antibody IAM-41-2F5 ( 2F5) were determined in cell culture and showed that neutralization was related to the presence of the antibody binding site.
Journal ArticleDOI
Neutralization of primary human immunodeficiency virus type 1 isolates by the broadly reactive anti-V3 monoclonal antibody, 447-52D.
Anthony J. Conley,M K Gorny,Joseph Kessler,Lynn J. Boots,M Ossorio-Castro,S Koenig,D W Lineberger,Emilio A. Emini,Constance Williams,Susan Zolla-Pazner +9 more
TL;DR: The study demonstrated that neutralization of primary HIV-1 isolates is possible if mediated by an appropriate antibody, and confirmed that this determinant is commonly expressed by virus isolates belonging to the subtype (clade) B sequence classification.
Journal ArticleDOI
The consequence of passive administration of an anti-human immunodeficiency virus type 1 neutralizing monoclonal antibody before challenge of chimpanzees with a primary virus isolate.
Anthony J. Conley,Joseph Kessler,Lynn J. Boots,Philip M. McKenna,William A. Schleif,Emilio A. Emini,George E. Mark,Hermann Katinger,E K Cobb,S M Lunceford,S R Rouse,K K Murthy +11 more
TL;DR: This antibody infusion study indicates that neutralizing antibody, when present at the time of challenge, affects the timing and level of infection and remains influential after it can no longer be detected in the peripheral circulation.
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Potent 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists: effects of fused heterocycles on antiviral activity and pharmacokinetic properties.
Dooseop Kim,Liping Wang,Jeffrey J. Hale,Christopher L. Lynch,Richard J. Budhu,Malcolm MacCoss,Sander G. Mills,Lorraine Malkowitz,Sandra L. Gould,Julie A. DeMartino,Martin S. Springer,Daria J. Hazuda,Michael W. Miller,Joseph Kessler,Renee Hrin,Gwen Carver,Anthony Carella,Karen Henry,Janet Lineberger,William A. Schleif,Emilio A. Emini +20 more
TL;DR: A series of 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists containing a variety of fused heterocycles at the 4-position of the piperidine side chain has been discovered, which are orally bioavailable with potent anti-HIV activity.
Journal ArticleDOI
Antagonists of the human CCR5 receptor as anti-HIV-1 agents. Part 4: synthesis and structure–Activity relationships for 1-[N-(Methyl)-N-(phenylsulfonyl)amino]-2-(phenyl)-4-(4-(N-(alkyl)-N-(benzyloxycarbonyl)amino)piperidin-1-yl)butanes
Paul E. Finke,Bryan Oates,Sander G. Mills,Malcolm MacCoss,Lorraine Malkowitz,Martin S. Springer,Sandra L. Gould,Julie A. DeMartino,Anthony Carella,Gwen Carver,Karen Holmes,Renee Danzeisen,Daria J. Hazuda,Joseph Kessler,Janet Lineberger,Michael W. Miller,William A. Schleif,Emilio A. Emini +17 more
TL;DR: In this paper, structure-activity relationship studies of non-spiro piperidines are described, which led to the discovery of 4-(N-(alkyl)-N-(benzyloxycarbonyl)amino)piperidine derivatives (3-5) as potent CCR5 antagonists.