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Joseph Leo Ghislanus Torremans

Researcher at Janssen Pharmaceutica

Publications -  23
Citations -  574

Joseph Leo Ghislanus Torremans is an academic researcher from Janssen Pharmaceutica. The author has contributed to research in topics: Bicyclic molecule & Astemizole. The author has an hindex of 11, co-authored 22 publications receiving 571 citations.

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Patent

4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines

Frans Eduard Janssens, +4 more
TL;DR: In this paper, 4.4-[(Bicyclic heterocyclyl)methyl and -hetero]-piperidines having antihistaminic and serotonin-antagonistic properties are useful agents in the treatment of allergic diseases.
Journal ArticleDOI

New antihistaminic N-heterocyclic 4-piperidinamines. 1. Synthesis and antihistaminic activity of N-(4-piperidinyl)-1H-benzimidazol-2-amines.

Janssens Frans Eduard, +5 more
- 01 Dec 1985 - 
TL;DR: The phenylethyl derivatives showed the most potent antihistamine properties after oral administration in both animal species and in vivo antihistaminic activity was evaluated.
Patent

N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives

Frans Eduard Janssens, +3 more
TL;DR: Novel N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives having antihistaminic properties which compounds are useful in the treatment of allergic diseases.
Journal ArticleDOI

New antihistaminic N-heterocyclic 4-piperidinamines. 2. Synthesis and antihistaminic activity of 1-[(4-fluorophenyl)methyl]-N-(4-piperidinyl)-1H-benzimidazol-2-a mines.

Janssens Frans Eduard, +5 more
- 01 Dec 1985 - 
TL;DR: The synthesis of a series of 1-[(4-fluorophenyl)methyl]-N-(4-piperidinyl)-1H-benzimidazol-2-ami nes and the preliminary evaluation of their in vivo antihistamine activity are described and Astemizole has been selected for clinical investigation.
Journal ArticleDOI

New antihistaminic N-heterocyclic 4-piperidinamines. 3. Synthesis and antihistaminic activity of N-(4-piperidinyl)-3H-imidazo[4,5-b]pyridin-2-amines.

Janssens Frans Eduard, +5 more
- 01 Dec 1985 - 
TL;DR: To study the bioisosteric replacement of a 2-pyridyl ring for a phenyl nucleus in astemizole, a series of N-(4-piperidinyl)-3H-imidazo[4,5-b]pyridine-2-amines was synthesized and evaluated.