Patent
4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines
Frans Eduard Janssens,Ludo Edmond Josephine Kennis,Jozef Francis Hens,Joseph Leo Ghislanus Torremans,Gaston Stanislas Marcella Diels +4 more
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TLDR
In this paper, 4.4-[(Bicyclic heterocyclyl)methyl and -hetero]-piperidines having antihistaminic and serotonin-antagonistic properties are useful agents in the treatment of allergic diseases.Abstract:
4-[(Bicyclic heterocyclyl)methyl and -hetero]-piperidines having antihistaminic and serotonin-antagonistic properties which compounds are useful agents in the treatment of allergic diseases.read more
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Quinazoline derivatives as medicaments
Sarvajit Chakravarty,Sundeep Dugar,John J. Perumattam,George F. Schreiner,David Y. Liu,John A. Lewicki +5 more
TL;DR: In this article, a method to inhibit TGF-β and/or p38-α kinase using compounds of formula (1) or the pharmaceutically acceptable salts thereof was proposed.
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N-ureidoalkyl-piperidines as modulators of chemokine receptor activity
TL;DR: In this article, the authors describe modulators of CCR3 of formula (I) or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma and other allergic diseases.
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Respiratory syncytial virus replication inhibitors
Frans Eduard Janssens,Kathleen P Meersman,Francois Maria Sommen,Jerome Emile Georges Guillemont,Jean Fernand Armand Lacrampe,Koenraad Jozef Lodewijk Marcel Andries +5 more
TL;DR: In this article, the compounds of formula (I), prodrugs, Noxides, addition salts, quaternary amines, metal complexes or stereochemically isomeric forms thereof are defined.
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1,2-benzisoxazol-3-yl and 1,2-benzisothiazol-3-yl derivatives
TL;DR: In this paper, the authors proposed a novel 3-piperidinyl-1,2-benzisothiazoles and 1-2-bensisoxazoles having the formula wherein X is O or S and Q is a radical of formula or a radical-of-formula, and possible stereochemically isomeric forms thereof.
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2-aminopyrimidinone derivatives
TL;DR: Amino-pyrimidininone derivatives possessing antihistaminic and serotonin-antagonistic properties were used as the active ingredient of compositions containing these compounds as the effective ingredient and a method of treating subjects from allergic diseases as mentioned in this paper.
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Patent
Piperidinylalkyl quinazoline compounds, composition and method of use
Vandenberk Jan,Kennis Ludo Edmond Josephine,Heertum Albert Henricus Maria,Aa Marcel Josef Maria Catharin +3 more
TL;DR: Novel quinazoline derivatives, comprising in the heterocyclic part of their nucleus at least one carbonyl or thiocarbonyl group and a particularly substituted piperidinyl-alkyl side chain, have been found to be potent serotonin-antagonists as discussed by the authors.
Patent
N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives
Frans Eduard Janssens,Joseph Leo Ghislanus Torremans,Jozef Francis Hens,Theophilus Theresia J.M. Van Offenwert +3 more
TL;DR: Novel N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives having antihistaminic properties which compounds are useful in the treatment of allergic diseases.
Patent
N-(Bicyclic heterocyclyl)-4-piperidinamines
Frans Eduard Janssens,Joseph Leo Ghislanus Torremans,Jozef Francis Hens,Theophilus Theresia J.M. Van Offenwert +3 more
TL;DR: Novel N-(bicyclic heterocyclyl)-4-piperidinamines having antihistaminic and serotonin-antagonistic properties which are useful in the treatment of allergic diseases as mentioned in this paper.
Patent
N-Heterocyclyl-4-piperidinamines
Frans Eduard Janssens,Raymond Antoine Stokbroekx,Joseph Leo Ghislanus Torremans,Marcel Gerebernus Maria Luyckx +3 more
TL;DR: In this article, N-heterocyclyl-4-piperidinamines where the heterocyclic radical is an optionally substituted 1H-benzimidazol-2-yl or 3H-imidazo[4,5b]pyridin-2yl radical, said compounds being useful as antihistaminic agents.
Patent
Bicyclic heterocyclyl containing n-(bicyclic heterocyclyl)-4-piperidinamines
Frans Eduard Janssens,Joseph Leo Ghislanus Torremans,Jozef Francis Hens,Theophilus Theresia J.M. Van Offenwert +3 more
TL;DR: Bicyclic heterocyclyl containing 4-piperidinamines have antihistaminic and serotonin-antagonistic properties which compounds are useful agents in the treatment of allergic diseases as mentioned in this paper.