J
Joseph M. Hendricks
Researcher at University of California, Berkeley
Publications - 2
Citations - 1317
Joseph M. Hendricks is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: GPX4 & Inducer. The author has an hindex of 1, co-authored 1 publications receiving 492 citations.
Papers
More filters
Journal ArticleDOI
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis.
Kirill Bersuker,Joseph M. Hendricks,Zhipeng Li,Leslie Magtanong,Breanna Ford,Peter H. Tang,Melissa A. Roberts,Bingqi Tong,Thomas J. Maimone,Roberto Zoncu,Michael C. Bassik,Daniel K. Nomura,Scott J. Dixon,James A. Olzmann +13 more
TL;DR: AFerroptosis suppressor protein 1 (FSP1) is identified as a key component of a non-mitochondrial CoQ antioxidant system that acts in parallel to the canonical glutathione-based GPX4 pathway, and pharmacological inhibition of FSP1 may provide an effective strategy to sensitize cancer cells to ferroPTosis-inducing chemotherapeutic agents.
Posted ContentDOI
Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis
Joseph M. Hendricks,Cody Doubravsky,Eddie Wehri,Zhipeng Li,Melissa A. Roberts,Kirandeep K. Deol,Mike Lange,Irene Lasheras-Otero,Scott J. Dixon,Kirill Bersuker,Julia Schaletzky,James A. Olzmann +11 more
TL;DR: In this paper , the authors identify several structurally diverse FSP1 inhibitors and demonstrate that FSEN1 synergizes with endoperoxide-containing ferroptosis inducers, including dihydroartemisinin, to trigger cancer cells to react to FSP.