M
Melissa A. Roberts
Researcher at University of California, Berkeley
Publications - 8
Citations - 1415
Melissa A. Roberts is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Lipid droplet & Medicine. The author has an hindex of 3, co-authored 4 publications receiving 529 citations.
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Journal ArticleDOI
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis.
Kirill Bersuker,Joseph M. Hendricks,Zhipeng Li,Leslie Magtanong,Breanna Ford,Peter H. Tang,Melissa A. Roberts,Bingqi Tong,Thomas J. Maimone,Roberto Zoncu,Michael C. Bassik,Daniel K. Nomura,Scott J. Dixon,James A. Olzmann +13 more
TL;DR: AFerroptosis suppressor protein 1 (FSP1) is identified as a key component of a non-mitochondrial CoQ antioxidant system that acts in parallel to the canonical glutathione-based GPX4 pathway, and pharmacological inhibition of FSP1 may provide an effective strategy to sensitize cancer cells to ferroPTosis-inducing chemotherapeutic agents.
Journal ArticleDOI
Protein Quality Control and Lipid Droplet Metabolism.
TL;DR: The mechanisms that regulate the composition of the LD proteome are reviewed, such as pathways that mediate selective and bulk LD protein degradation and potential connections between LDs and cellular protein quality control.
Journal ArticleDOI
Ribosome stalling during selenoprotein translation exposes a ferroptosis vulnerability in cancer
Zhipeng Li,Lucas Ferguson,Kirandeep K. Deol,Melissa A. Roberts,Leslie Magtanong,Michael C. Bassik,Scott J. Dixon,Nicholas T. Ingolia,James A. Olzmann +8 more
TL;DR: In this paper , a chemical-genetic screen was used to identify LRP8 (also known as ApoER2) as a ferroptosis resistance factor that is upregulated in cancer.
Journal ArticleDOI
Lipid disequilibrium disrupts ER proteostasis by impairing ERAD substrate glycan trimming and dislocation
Milton To,Clark W.H. Peterson,Melissa A. Roberts,Jessica L. Counihan,Tiffany Wu,Mercedes S. Forster,Daniel K. Nomura,James A. Olzmann +7 more
TL;DR: The disruptions in ER proteostasis activate the IRE1 and PERK branches of the unfolded protein response and ultimately induce I RE1-dependent cell death.
Journal ArticleDOI
Organelle Biogenesis: ER Shape Influences Lipid Droplet Nucleation.
TL;DR: A new study reveals that the high membrane curvature of ER tubules catalyzes the nucleation of a neutral lipid lens, an early step in LD biogenesis.