J
Joseph M. Malik
Researcher at University of Wisconsin-Madison
Publications - 2
Citations - 42
Joseph M. Malik is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Pyridoxal & Cofactor. The author has an hindex of 2, co-authored 2 publications receiving 42 citations.
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Kinetics and mechanism of the binding of pyridoxal 5'-phosphate to apoglutamate decarboxylase. Evidence for a rate-determining conformation change.
TL;DR: The rate constant for the binding of the coenzyme under optimum conditions is at least 100-fold smaller than that predicted from model reactions.
Journal ArticleDOI
Kinetics of the binding of pyridoxal 5'-phosphate to glutamate decarboxylase.
TL;DR: The rate of binding of pyridoxal 5'-phosphate to apoglutamate decarboxylase has been measured as a function of coenzyme concentration at 20°, pH 4.9, and first order kinetics is observed for at least three half-lives.