THE DESIGN AND ANALYSIS OF EXPERIMENTS. By Oscar Kempthorne. New York, John Wiley and Sons, Inc., 1952. 631 pp. $8.50. This book by a teacher of statistics (as well as a consultant for \"experimenters\") is a comprehensive study of the philosophical background for the statistical design of experiment. It is necessary to have some facility with algebraic notation and manipulation to be able to use the volume intelligently. The problems are presented from the theoretical point of view, without such practical examples as would be helpful for those not acquainted with mathematics. The mathematical justification for the techniques is given. As a somewhat advanced treatment of the design and analysis of experiments, this volume will be interesting and helpful for many who approach statistics theoretically as well as practically. With emphasis on the \"why,\" and with description given broadly, the author relates the subject matter to the general theory of statistics and to the general problem of experimental inference. MARGARET J. ROBERTSON

The Design and Analysis of Experiments

Individuals regulate their emotions in a wide variety of ways. Are some forms of emotion regulation healthier than others? We focus on two commonly used emotion regulation strategies: reappraisal (changing the way one thinks about a potentially emotion-eliciting event) and suppression (changing the way one responds behaviorally to an emotion-eliciting event). In the first section, we review experimental findings showing that reappraisal has a healthier profile of short-term affective, cognitive, and social consequences than suppression. In the second section, we review individual-difference findings, which show that using reappraisal to regulate emotions is associated with healthier patterns of affect, social functioning, and well-being than is using suppression. In the third section, we consider issues in the development of reappraisal and suppression and provide new evidence for a normative shift toward an increasingly healthy emotion regulation profile during adulthood (i.e., increases in the use of reappraisal and decreases in the use of suppression).

Healthy and Unhealthy Emotion Regulation: Personality Processes, Individual Differences, and Life Span Development

Attachment theory (J. Bowlby, 1982/1969, 1973) is one of the most useful and generative frameworks for understanding both normative and individual-differences aspects of the process of affect regulation. In this article we focus mainly on the different attachment-related strategies of affect regulation that result from different patterns of interactions with significant others. Specifically, we pursue 3 main goals: First, we elaborate the dynamics and functioning of these affect-regulation strategies using a recent integrative model of attachment-system activation and dynamics (P. R. Shaver & M. Mikulincer, 2002). Second, we review recent findings concerning the cognitive consequences of attachment-related strategies following the arousal of positive and negative affect. Third, we propose some integrative ideas concerning the formation and development of the different attachment-related strategies.

Attachment Theory and Affect Regulation: The Dynamics, Development, and Cognitive Consequences of Attachment-Related Strategies

There is increasing concern that most current published research findings are false. The probability that a research claim is true may depend on study power and bias, the number of other studies on the same question, and, importantly, the ratio of true to no relationships among the relationships probed in each scientific field. In this framework, a research finding is less likely to be true when the studies conducted in a field are smaller; when effect sizes are smaller; when there is a greater number and lesser preselection of tested relationships; where there is greater flexibility in designs, definitions, outcomes, and analytical modes; when there is greater financial and other interest and prejudice; and when more teams are involved in a scientific field in chase of statistical significance. Simulations show that for most study designs and settings, it is more likely for a research claim to be false than true. Moreover, for many current scientific fields, claimed research findings may often be simply accurate measures of the prevailing bias. In this essay, I discuss the implications of these problems for the conduct and interpretation of research.

Why most published research findings are false

Publisher Summary This chapter introduces the basic concepts in Bowlby's attachment theory, covering both the normative aspects of the attachment behavioral system and individual differences. It presents an integrative model of attachment-system dynamics in adulthood. The attachment system is an inborn regulatory device that has important implications for personality and interpersonal behavior. The model describes the goals of each attachment strategy and their psychological manifestations and consequences. The chapter introduces major individual differences in the functioning of the attachment system. It presents a theoretical framework that makes sense of the cognitive operations and dynamic processes involved in the activation and functioning of the attachment system in adulthood. For this, a control-system model is proposed that integrates recent findings with earlier theoretical proposals by Bowlby. The chapter summarizes the diverse empirical studies motivated by the attachment theory and reviews a variety of unresolved conceptual and empirical issues that provide an agenda for future research.

The Attachment Behavioral System in Adulthood: Activation, Psychodynamics, and Interpersonal Processes.

SUMMARY The United Egg Producers husbandry guidelines for cages recommend a minimum of 432 to 555 cm 2 (67 to 86 in. 2 ) of usable space/hen, defined as floor space that is of sufficient height for hens to stand upright. Because there is neither a quantitative value given for cage height nor an established method for calculating usable space, meeting this guideline poses challenges for producers. The objectives of this study were to design a tool that could be used to calculate usable space and evaluate the effect of cage height on that space. Based on some reported hen behavior, it has been suggested that cage height should be at least 35.6 to 40.6 cm (14 to 16 in.), the effect of these height specifications on usable space was assessed. Using cage measurements taken from 180 commercial houses, we found that usable space declined as the specification for cage height increased from 30.5 to 47.0 cm (12 to 18.5 in.), with this decline occurring more rapidly for A-frame than vertical cages. When cage height was set at 35.6 cm (14 in.), almost all houses had cages with usable space. When it was set at 40.6 cm (16 in.), 97.5% of houses with vertical cages and only 30% of houses with A-frame cages had cages with any usable space. Although additional investigation into the effects of cage height on hen productivity and welfare is required to establish a scientifically justified cage height recommendation, this tool will be useful for producers and engineers in determining usable space across a range of hen strain sizes and cage designs.

A standardized cage measurement system: A versatile tool for calculating usable cage space1

Food is thought to synchronize circadian clocks in the body, but this is based on time-restricted feeding (TRF) protocols. To test whether naturalistic feeding patterns are sufficient to phase-shift and entrain peripheral tissues, we measured circadian rhythms of the liver, kidney, and submandibular gland in mPer2Luc mice under different feeding schedules. In ad lib feeding as well as in a schedule designed to mimic the ad lib pattern, PER2::LUC bioluminescence peaked during the night as expected. Surprisingly, shifting the scheduled feeding by 12h caused only small advances (

https://biorxiv.org/content/10.1101/2020.07.28.220509v1.full.pdf

Natural food intake patterns do not synchronize peripheral clocks

The present disclosure provides a method of diagnosing neurological disorders including for example, impulse control disorders, such as barbering and trichotillomania using biomarkers such as reductive capacity of urine and 8-OH-dG concentration. Still other disorders that can be diagnosed based on the measurements of makers for oxidative stress include autism and Parkinson's disease.

Method of diagnosing trichotillomania and similar disorders in humans and rodents

A long held view in the spinal cord injury field is that corticospinal terminal sprouting is needed for new connections to form that then mediate behavioral recovery. The inference is that more extensive sprouting predicts greater recovery, though there is little evidence to support this. Here we compare behavioral data from two established deafferentation injury models in monkeys, to provide a clear example that sprouting does not track with behavioral recovery.

/pdf/behavioral-recovery-after-a-spinal-deafferentation-injury-in-20l4izk0sn.pdf

Behavioral recovery after a spinal deafferentation injury in monkeys does not correlate with corticospinal sprouting

https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cne.25425

Joseph P. Garner

Papers

A standardized cage measurement system: A versatile tool for calculating usable cage space1

Natural food intake patterns do not synchronize peripheral clocks

Method of diagnosing trichotillomania and similar disorders in humans and rodents

Behavioral recovery after a spinal deafferentation injury in monkeys does not correlate with corticospinal sprouting

Cover Image, Volume 530, Issue 17