J
Joseph R. Ghilardi
Researcher at Veterans Health Administration
Publications - 79
Citations - 10301
Joseph R. Ghilardi is an academic researcher from Veterans Health Administration. The author has contributed to research in topics: Bone cancer & Nociception. The author has an hindex of 56, co-authored 79 publications receiving 9735 citations. Previous affiliations of Joseph R. Ghilardi include University of Cincinnati Academic Health Center & University of Minnesota.
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Journal ArticleDOI
Inhibition of hyperalgesia by ablation of lamina I spinal neurons expressing the substance P receptor.
Patrick W. Mantyh,Scott D. Rogers,Scott D. Rogers,Prisca Honore,Prisca Honore,Brian J. Allen,Brian J. Allen,Joseph R. Ghilardi,Joseph R. Ghilardi,Jun Li,Randy S. Daughters,Douglas A. Lappi,Ronald G. Wiley,Donald A. Simone +13 more
TL;DR: In this paper, a conjugate of substance P and the ribosome-inactivating protein saporin was infused into the spinal cord, and it was internalized and cytotoxic to lamina I spinal cord neurons that express the substance P receptor.
Journal ArticleDOI
Aluminum, Iron, and Zinc Ions Promote Aggregation of Physiological Concentrations of β‐Amyloid Peptide
Patrick W. Mantyh,Joseph R. Ghilardi,Scott D. Rogers,Eric DeMaster,Clark J. Allen,Evelyn R. Stimson,John E. Maggio +6 more
TL;DR: High concentrations of certain metals may play a role in the pathogenesis of AD by promoting aggregation of human βA4, a 40‐mer whose neurotoxicity is related to its aggregation.
Journal ArticleDOI
Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation
Patrick W. Mantyh,Patrick W. Mantyh,Eric DeMaster,Eric DeMaster,Amit Malhotra,Joseph R. Ghilardi,Joseph R. Ghilardi,Scott D. Rogers,Scott D. Rogers,Christopher R. Mantyh,Hantao Liu,Allan I. Basbaum,Steven R. Vigna,John E. Maggio,Donald A. Simone +14 more
TL;DR: In vivo somatosensory stimuli evoked the release of substance P from primary afferent neurons that terminate in the spinal cord and stimulated endocytosis of Substance P receptors in rat spinal cord neurons, providing a specific image of neurons activated by substance P.
Journal ArticleDOI
Transmission of chronic nociception by spinal neurons expressing the substance P receptor.
Michael L. Nichols,Michael L. Nichols,Brian J. Allen,Brian J. Allen,Scott D. Rogers,Scott D. Rogers,Joseph R. Ghilardi,Joseph R. Ghilardi,Prisca Honore,Prisca Honore,Nancy M. Luger,Nancy M. Luger,Matthew P. Finke,Matthew P. Finke,Jun Li,Douglas A. Lappi,Donald A. Simone,Patrick W. Mantyh,Patrick W. Mantyh +18 more
TL;DR: It is suggested that the small population of SPR-expressing neurons in the dorsal horn of the spinal cord plays a pivotal role in the generation and maintenance of chronic neuropathic and inflammatory pain.
Journal ArticleDOI
Fibrillar β-Amyloid Induces Microglial Phagocytosis, Expression of Inducible Nitric Oxide Synthase, and Loss of a Select Population of Neurons in the Rat CNS In Vivo
D.T. Weldon,Scott D. Rogers,Joseph R. Ghilardi,Matthew P. Finke,James P. Cleary,Eugene O'Hare,Eugene O'Hare,William P. Esler,John E. Maggio,Patrick W. Mantyh +9 more
TL;DR: FAβ is remarkably stable in the CNS in vivo and suggest that fAβ neurotoxicity is mediated in large part by factors released from activated microglia and astrocytes, as opposed to direct interaction between Aβ fibrils and neurons.