On the size of the active site in proteases. I. Papain.

Acetylornithinase of Escherichia coli: partial purification and some properties.

The preparation and properties of two new chromogenic substrates of trypsin.

https://www.farm.ucl.ac.be/Full-texts-FARM/Danhier-2010-2.pdf

To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery

The spectrophotometric procedure proposed by Schwert and Takenaka for the assay of chymotrypsin and trypsin has been modified and extended to include the application to N-benzoyl-L-tyrosine ethyl e...

A modified spectrophotometric determination of chymotrypsin, trypsin, and thrombin.

http://www.jbc.org/content/194/2/793.full.pdf

On the proteolytic enzymes of animal tissues. X. Beef spleen cathepsin C.

CHEMICAL REACTIONS OF THE NITROGEN MUSTARD GASES.1 I. THE TRANSFORMATIONS OF METHYL-BIS(β-CHLOROETHYL)AMINE IN WATER

Studies on gastric digestion during 1820–1840 led to the discovery of pepsin as the agent which, in the presence of stomach acid, causes the dissolution of nutrients such as meat or coagulated egg white. Soon afterward it was shown that these protein nutrients were cleaved by pepsin to diffusible products named peptones. Efforts to isolate and purify pepsin were spurred by its widespread adoption for the treatment of digestive disorders, and highly active preparations were available by the end of the nineteenth century. There was uncertainty, however, as to the chemical nature of pepsin, for some preparations exhibited the properties of proteins while other preparations failed to do so. The question was not settled until after 1930, when Northrop crystallized swine pepsin and provided convincing evidence for its identity as a protein. The availability of this purified pepsin during the 1930s also led to the discovery of the first synthetic peptide substrates for pepsin, thus providing needed evid...

Joseph S. Fruton

Papers

On the proteolytic enzymes of animal tissues. X. Beef spleen cathepsin C.

CHEMICAL REACTIONS OF THE NITROGEN MUSTARD GASES.1 I. THE TRANSFORMATIONS OF METHYL-BIS(β-CHLOROETHYL)AMINE IN WATER

A History Of Pepsin And Related Enzymes

The Mechanism of the Catalytic Action of Pepsin and Related Acid Proteinases

Studies on the specificity of pepsin.