EXCESSIVE consumption of alcohol was known to be related to liver disease before the time of Hippocrates, but the recognition of alcohol-related diseases that affect cardiac and skeletal muscle is ...

Alcoholic Myopathy in Heart and Skeletal Muscle

Chronic ethanol consumption leads to a number of alterations in the contractile function of the heart and is a leading cause of cardiomyopathy. Ethanol also has an acute negative inotropic effect mediated by direct interaction with cardiac muscle cells, although this action is often masked by indirect actions resulting from enhanced release of catecholamines in vivo. This article reviews the effects of ethanol on the contractile function of the heart. The specific targets affected by ethanol in cardiac muscle cells are discussed in terms of potential mechanisms underlying the depressions of contractility resulting from both acute and chronic actions of ethanol.

Effects of ethanol on the contractile function of the heart : a review

Alcohol consumption and idiopathic dilated cardiomyopathy: A case control study

Representatives of eleven different classes of isoquinoline alkaloids inhibit Na+, K+-ATPase and Mg2+-ATPase in rat brain microsomal preparations In most cases the Na+, K+-ATPase is more sensitive than Mg2+-ATPase to inhibition by the alkaloids The classes of alkaloids can be ranked according to potency of inhibition of Na+, K+-ATPase Protoberberines are most effective, followed in decreasing order by benzophenanthridines, benzylisoquinolines, aporphines, tetrahydroprotoberberines, pavines, protopines, isoquinolines, tetrahydrobenzylisoquinolines, morphinanes, and tetrahydroisoquinolines As specific representatives of each of the first four classes of alkaloids, berberine, sanguinarine, papaveroline and 1,2,10,11-tetrahydroxyaporphine, respectively, prove most valuable in kinetic studies because they exhibit the greatest inhibitory action on brain Na+, K+-ATPase Kinetic analyses plotted in double reciprocal form reveal that berberine and 1,2,10,11-tetrahydroxyaporphine are simple linear competitive inhibitors with respect to ATP, whereas sanguinarine and papaveroline are simple linear noncompetitive inhibitors These four representative alkaloids exhibit non-linear competitive inhibition with respect to Na+-activation Additionally, these alkaloids significantly inhibit rat brain microsomal K+-activated pNPPase The results demonstrate that certain members of several classes of isoquinoline alkaloids markedly affect various cation-dependent phosphohydrolases in vitro

Isoquinoline alkaloids. Inhibitory actions on cation-dependent ATP-phosphohydrolases.

http://link.springer.com/content/pdf/10.1007/978-1-4615-7734-8_4.pdf

Joseph W. Williams

Papers

Effect of ethanol and acetaldehyde on the (Na+ + K+)-activated adenosine triphosphatase activity of cardiac plasma membranes