Journal ArticleDOI
Effect of ethanol and acetaldehyde on the (Na+ + K+)-activated adenosine triphosphatase activity of cardiac plasma membranes
Reads0
Chats0
TLDR
Ethanol and acetaldehyde inhibited the (Na + + K + )-activated ATPase activity of plasma membranes prepared from the guinea-pig heart by dose-dependent and antagonized by the K + concentration in the reaction mixture.About:
This article is published in Biochemical Pharmacology.The article was published on 1975-01-01. It has received 74 citations till now. The article focuses on the topics: Acetaldehyde & Ethanol.read more
Citations
More filters
Journal ArticleDOI
Alcoholic Myopathy in Heart and Skeletal Muscle
TL;DR: The recognition of alcohol-related diseases that affect cardiac and skeletal muscle is recognized and these diseases are known to be related to liver disease before the time of Hippocrates.
Journal ArticleDOI
Effects of ethanol on the contractile function of the heart : a review
TL;DR: The specific targets affected by ethanol in cardiac muscle cells are discussed in terms of potential mechanisms underlying the depressions of contractility resulting from both acute and chronic actions of ethanol.
Journal ArticleDOI
Alcohol consumption and idiopathic dilated cardiomyopathy: A case control study
TL;DR: This study confirms previous suspicion of a causal association between alcohol and DCM, with significantly more patients than members of the control group either abusing alcohol or drinking it in excess of recommended limits.
Journal ArticleDOI
Isoquinoline alkaloids. Inhibitory actions on cation-dependent ATP-phosphohydrolases.
TL;DR: Kinetic analyses plotted in double reciprocal form reveal that berberine and 1,2,10,11-tetrahydroxyaporphine are simplelinear competitive inhibitors with respect to ATP, whereas sanguinarine and papaveroline are simple linear noncompetitive inhibitors.
References
More filters
Journal ArticleDOI
A microcolorimetric method for the determination of inorganic phosphorus.
Hertha H. Taussky,Ephraim Shorr +1 more
Journal ArticleDOI
Enzymatic basis for active transport of na+ and k+ across cell membrane.
TL;DR: Afhnity for Monovalent Cations and Quantitative Relation between Effect of Na+ + K+ on Enzyme System and Active Transport in Intact Cell.
Journal ArticleDOI
Characterization of dog cardiac microsomes. Use of zonal centrifugation to fractionate fragmented sarcoplasmic reticulum, (Na+ + K+)--activated ATPase and mitochondrial fragments.
TL;DR: Cardiac microsomes represent a heterogeneous fraction which contains mitochondrial, plasma membrane and lysosomal enzymes in addition to markers believed to originate in the sarcoplasmic reticulum in that prolonged homogenization of ventricular myocardium increases both the yield of microsomal protein and the proportion of the mitochondrial contaminant.
Journal ArticleDOI
Effects of ethanol on na, K, mg-stimulated microsomal ATPase activity.
TL;DR: Ethanol intoxication in rats, measured by the inclined-plane test, was less severe when the ethanol was injected in KCl solution than when given in NaCl, and is taken as evidence that inhibition of active transport of K+ plays an important role in ethanol intoxication in vivo.
Journal ArticleDOI
The effect of acetaldehyde on mitochondrial function
Arthur I. Cederbaum,Arthur I. Cederbaum,Charles S. Lieber,Charles S. Lieber,Emanuel Rubin,Emanuel Rubin +5 more
TL;DR: The data suggest that acetaldehyde may be implicated in some of the toxic effects caused by chronic ethanol consumption, as the malate-aspartate, α-glycerophosphate, and fatty acid shuttles for the transfer of reducing equivalents, and oxidation by mitochondria, were highly sensitive to acetaldehyde.