J
Josue G. Yague
Researcher at Spanish National Research Council
Publications - 17
Citations - 933
Josue G. Yague is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Aromatase & Cerebral cortex. The author has an hindex of 12, co-authored 16 publications receiving 847 citations. Previous affiliations of Josue G. Yague include Icahn School of Medicine at Mount Sinai & Cardiff University.
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Journal ArticleDOI
Estradiol synthesis within the human brain.
TL;DR: In this review, the existing data related with the detection of aromatase in human brain is summarized, with particular emphasis in the so-called "non-primary reproductive" areas, including hypothalamus, amygdala and preoptic/septal areas.
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Aromatase expression in the human temporal cortex
Josue G. Yague,Alberto Muñoz,P. de Monasterio-Schrader,Javier DeFelipe,Luis M. Garcia-Segura,Iñigo Azcoitia +5 more
TL;DR: The broad range of potential modulators of the cyp19 gene in the cortex and the widespread expression of the protein in specific neuronal and glial subpopulations suggest that local estrogen formation may play an important role in human cortical function.
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Spinal Cord Injury Immediately Changes the State of the Brain
Juan Aguilar,Desire Humanes-Valera,Elena Alonso-Calviño,Josue G. Yague,Karen A. Moxon,Antonio Oliviero,Guglielmo Foffani +6 more
TL;DR: It is shown that a complete thoracic transection of the spinal cord produces immediate functional reorganization in the primary somatosensory cortex of anesthetized rats, and that this state change plays a critical role in the early cortical reorganization after spinal cord injury.
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Aromatase Distribution in the Monkey Temporal Neocortex and Hippocampus
Josue G. Yague,Athena Ching-Jung Wang,William G.M. Janssen,Patrick R. Hof,Luis M. Garcia-Segura,Iñigo Azcoitia,John H. Morrison +6 more
TL;DR: The widespread expression of the protein in a large neuronal population suggests that local intraneuroral estrogen synthesis may contribute to estrogen-induced synaptic plasticity in monkey hippocampus and neocortex of female rhesus monkeys.
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Interactions between neuroactive steroids and reelin haploinsufficiency in Purkinje cell survival.
Filippo Biamonte,Giovanni Assenza,Ramona Marino,Marcello D'Amelio,Roger Panteri,Donatella Caruso,Samuele Scurati,Josue G. Yague,Luis M. Garcia-Segura,Roberta Cesa,Piergiorgio Strata,Roberto Cosimo Melcangi,Flavio Keller +12 more
TL;DR: RT-PCR analysis indicated that heterozygosity leads to a 50% reduction of reelin RNA in the cerebellum in both sexes, as expected, and that 17beta-E upregulates reelin mRNA, particularly in rl/+ males; reelinRNA upregulation is associated with an increase of all major reelin isoforms.