J
Joyce M. Sherman
Researcher at University of Colorado Boulder
Publications - 4
Citations - 884
Joyce M. Sherman is an academic researcher from University of Colorado Boulder. The author has contributed to research in topics: Gene silencing & Gene. The author has an hindex of 4, co-authored 4 publications receiving 850 citations.
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Journal ArticleDOI
The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability.
Carrie Baker Brachmann,Joyce M. Sherman,Scott E. Devine,Elizabeth E. Cameron,Lorraine Pillus,Jef D. Boeke +5 more
TL;DR: The discovery of four Saccharomyces cerevisiae homologs of the SIR2 silencing gene (HSTs), as well as conservation of this gene family from bacteria to mammals are reported, establishing new connections between silencing and these fundamental cellular processes.
Journal ArticleDOI
The Conserved Core of a Human SIR2 Homologue Functions in Yeast Silencing
Joyce M. Sherman,Elisa M. Stone,Lisa L. Freeman-Cook,Carrie Baker Brachmann,Jef D. Boeke,Lorraine Pillus +5 more
TL;DR: Results support a model for the involvement of distinct Sir2p-containing complexes in HM/telomeric and rDNA silencing and that HST family members, including the widely expressed hSir2A, may perform evolutionarily conserved functions.
Journal ArticleDOI
The Schizosaccharomyces pombe hst4+ gene is a SIR2 homologue with silencing and centromeric functions
Lisa L. Freeman-Cook,Joyce M. Sherman,Carrie Baker Brachmann,Robin C. Allshire,Jef D. Boeke,Lorraine Pillus +5 more
TL;DR: It is demonstrated that a SIR-like silencing mechanism is conserved in the distantly related yeasts and is likely to be found in other organisms from prokaryotes to mammals.
Journal ArticleDOI
An uncertain silence
Joyce M. Sherman,Lorraine Pillus +1 more
TL;DR: The recent discovery of conserved gene families encoding proteins related to modulators of acetylation and deacetylation suggests mechanisms for differential regulation of silencing at known loci and the existence of additional, as yet undiscovered, silenced loci.