J
Juan A. González-Vera
Researcher at University of Granada
Publications - 48
Citations - 732
Juan A. González-Vera is an academic researcher from University of Granada. The author has contributed to research in topics: Nitrile & Kinase activity. The author has an hindex of 13, co-authored 44 publications receiving 562 citations. Previous affiliations of Juan A. González-Vera include Spanish National Research Council & Centre national de la recherche scientifique.
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Recognition-Domain Focused Chemosensors: Versatile and Efficient Reporters of Protein Kinase Activity
TL;DR: A new, recognition-domain focused (RDF) strategy was developed that allows inclusion of extended binding determinants to maximize recognition by the cognate kinase, which has now permitted the construction of chemosensors for a variety of representative Ser/Thr kinases with greatly enhanced selectivity.
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Probing the kinome in real time with fluorescent peptides
TL;DR: This tutorial review briefly summarizes the different fluorescent continuous peptide-based strategies that are being commonly employed to sense protein phosphorylation, introduces a few novel and attractive emerging assays, and discusses their advantages and limitations, and highlights possible future directions.
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Synthesis of red-shifted 8-hydroxyquinoline derivatives using click chemistry and their incorporation into phosphorylation chemosensors.
TL;DR: In this paper, a red-shifted 8-hydroxyquinoline-based fluorophores and their incorporation into peptidyl kinase activity reporters were described. But the authors did not describe the synthesis of the new fluorophore.
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Fluorescent Reporters and Biosensors for Probing the Dynamic Behavior of Protein Kinases
TL;DR: Current technologies to probe different dynamic features of protein kinases are reviewed and limitations where new developments are required are discussed, in particular with respect to infrared and near-infrared fluorescent probes and strategies which enable improved signal-to-noise ratio and controlled activation of probes.
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A new serotonin 5-HT 6 receptor antagonist with procognitive activity - Importance of a halogen bond interaction to stabilize the binding
Juan A. González-Vera,Rocío A Medina,Mar Martín-Fontecha,Angel Gonzalez,Tania de la Fuente,Henar Vázquez-Villa,Javier García-Cárceles,Joaquin Botta,Peter J. McCormick,Bellinda Benhamú,Leonardo Pardo,María L. López-Rodríguez +11 more
TL;DR: In vitro pharmacological characterization and site-directed mutagenesis and homology models show the importance of a halogen bond interaction between a chlorine atom of the new class of 5-HT6 receptor antagonists identified herein and a backbone carbonyl group in transmembrane domain 4.