J
Juan-Carlos Alvarez-Perez
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 1
Citations - 296
Juan-Carlos Alvarez-Perez is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Beta (finance) & Embryonic stem cell. The author has an hindex of 1, co-authored 1 publications receiving 235 citations.
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A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication
Peng Wang,Juan-Carlos Alvarez-Perez,Dan P. Felsenfeld,Hongtao Liu,Sharmila Sivendran,Aaron Bender,Anil Kumar,Roberto Sanchez,Donald K. Scott,Adolfo Garcia-Ocaña,Andrew F. Stewart +10 more
TL;DR: Using three different mouse and human islet in vivo–based models, harmine is able to induce beta cell proliferation, increase islet mass and improve glycemic control, suggesting that harmine analogs may have unique therapeutic promise for human diabetes therapy.