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Adolfo Garcia-Ocaña
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 133
Citations - 7103
Adolfo Garcia-Ocaña is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Islet & Beta cell. The author has an hindex of 45, co-authored 109 publications receiving 6209 citations. Previous affiliations of Adolfo Garcia-Ocaña include University of Pittsburgh.
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Journal ArticleDOI
Intermittent Hypoxia Causes Insulin Resistance in Lean Mice Independent of Autonomic Activity
Nao Iiyori,Laura C. Alonso,Jianguo Li,Mark H. Sanders,Adolfo Garcia-Ocaña,Robert M. O'Doherty,Vsevolod Y. Polotsky,Christopher P. O'Donnell +7 more
TL;DR: It is concluded that IH can cause acute insulin resistance in otherwise lean, healthy animals, and that the response is associated with decreased glucose utilization of oxidative muscle fibers, but that it occurs independently of activation of the ANS.
Journal ArticleDOI
A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication
Peng Wang,Juan-Carlos Alvarez-Perez,Dan P. Felsenfeld,Hongtao Liu,Sharmila Sivendran,Aaron Bender,Anil Kumar,Roberto Sanchez,Donald K. Scott,Adolfo Garcia-Ocaña,Andrew F. Stewart +10 more
TL;DR: Using three different mouse and human islet in vivo–based models, harmine is able to induce beta cell proliferation, increase islet mass and improve glycemic control, suggesting that harmine analogs may have unique therapeutic promise for human diabetes therapy.
Journal ArticleDOI
Hepatocyte Growth Factor Overexpression in the Islet of Transgenic Mice Increases Beta Cell Proliferation, Enhances Islet Mass, and Induces Mild Hypoglycemia
Adolfo Garcia-Ocaña,Karen K. Takane,Mushtaq A. Syed,William M. Philbrick,Rupangi C. Vasavada,Andrew F. Stewart +5 more
TL;DR: It is concluded that the overexpression of HGF in the islet increases beta cell proliferation, islet number, beta cell mass, and total insulin production in vivo, which results in mild hypoglycemia and resistance to the diabetogenic effects of streptozotocin.
Journal ArticleDOI
Glucose Infusion in Mice: A New Model to Induce β-Cell Replication
Laura C. Alonso,Takuya Yokoe,Pili Zhang,Donald K. Scott,Seung K. Kim,Christopher P. O'Donnell,Adolfo Garcia-Ocaña +6 more
TL;DR: A new model to study the regulation of compensatory β- cell replication is developed, and important novel characteristics of mouse β-cell responses to glucose in the living pancreas are described.
Journal ArticleDOI
MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism.
Emelyn H. Shroff,Livia S. Eberlin,Vanessa M. Dang,Arvin M. Gouw,Meital Gabay,Stacey J. Adam,David I. Bellovin,Phuoc T. Tran,William M. Philbrick,Adolfo Garcia-Ocaña,Stephanie C. Casey,Yulin Li,Chi V. Dang,Richard N. Zare,Dean W. Felsher +14 more
TL;DR: It is demonstrated through a conditional transgenic mouse model that MYC overexpression causes RCC and points to the inhibition of glutamine metabolism as a potential therapeutic approach for the treatment of this disease.