J
Juan Li
Researcher at Guangdong Pharmaceutical University
Publications - 3
Citations - 223
Juan Li is an academic researcher from Guangdong Pharmaceutical University. The author has contributed to research in topics: Protein kinase B & PI3K/AKT/mTOR pathway. The author has an hindex of 3, co-authored 3 publications receiving 173 citations.
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Journal ArticleDOI
NOX4 promotes non-small cell lung cancer cell proliferation and metastasis through positive feedback regulation of PI3K/Akt signaling
Cuixiang Zhang,Tian Lan,Jincai Hou,Juan Li,Rende Fang,Zhicheng Yang,Min Zhang,Jian-Xun Liu,Bing Liu +8 more
TL;DR: There existed a mutual positive regulation between NOX4 and PI3K/Akt signaling in NSCLC cells, andNOX4 was confirmed to functionally interplay with PI3k/AKT signaling to promote NSCLc cell proliferation and invasion.
Journal ArticleDOI
Reciprocal activation between IL-6/STAT3 and NOX4/Akt signalings promotes proliferation and survival of non-small cell lung cancer cells
Juan Li,Tian Lan,Cuixiang Zhang,Cheng Zeng,Jincai Hou,Zhicheng Yang,Min Zhang,Jian-Xun Liu,Bing Liu +8 more
TL;DR: NOX4 is confirmed to functionally interplay with IL-6 to promote NSCLC cell proliferation and survival and data indicate a novel NOX4-dependent link among IL- 6 in theNSCLC microenvironment, oxidative stress in NSCLc cells and autocrined IL-8 in NS CLC cells.
Journal ArticleDOI
NOX4 supports glycolysis and promotes glutamine metabolism in non-small cell lung cancer cells
TL;DR: Results reveal that NOX4 promotes glycolysis, contributing to NSCLC growth, and supports glutaminolysis for oxidative resistance, and may be a promising target to reverse malignant progression ofNSCLC.