J
Julia Reifenberger
Researcher at University of Düsseldorf
Publications - 120
Citations - 5628
Julia Reifenberger is an academic researcher from University of Düsseldorf. The author has contributed to research in topics: Loss of heterozygosity & Melanoma. The author has an hindex of 37, co-authored 118 publications receiving 5367 citations. Previous affiliations of Julia Reifenberger include Ludwig Institute for Cancer Research.
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Journal Article
Molecular genetic analysis of oligodendroglial tumors shows preferential allelic deletions on 19q and 1p.
Julia Reifenberger,Guido Reifenberger,Guido Reifenberger,Lu Liu,Lu Liu,C. D. James,W Wechsler,Vincent Peter Collins,Vincent Peter Collins +8 more
TL;DR: The loss of genetic information from 19q and 1p as well as the rarity of TP53 mutations in oligodendroglial tumors suggests that the early events in their oncogenesis are distinct from those associated with astrocytic tumors.
Journal Article
Missense Mutations in SMOH in Sporadic Basal Cell Carcinomas of the Skin and Primitive Neuroectodermal Tumors of the Central Nervous System
Julia Reifenberger,Marietta Wolter,Ruthild G. Weber,Mosaad Megahed,Thomas Ruzicka,Peter Lichter,Guido Reifenberger +6 more
TL;DR: The results indicate that both PTCH and SMOH represent important targets for genetic alterations in sporadic BCCs and PNETs.
Journal ArticleDOI
Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas
Julia Reifenberger,Marietta Wolter,Christiane B. Knobbe,B. Köhler,A. Schönicke,C. Scharwächter,K. Kumar,Britta Blaschke,Thomas Ruzicka,Guido Reifenberger +9 more
TL;DR: This study highlights the need to understand more fully the rationale behind the continued use of chemotherapy to treat basal cell carcinoma in women.
Journal Article
Mutations in the human homologue of the Drosophila segment polarity gene patched (PTCH) in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system
TL;DR: R reverse transcription-PCR analysis revealed increased PTCH expression levels compared to nonneoplastic brain tissue and normal skin in the majority of PNETs and BCCs investigated, suggesting that genetic alterations of PTCH are not only of significance in hereditary and sporadic BCCs but are also involved in the molecular pathogenesis of a subset of sporadic central nervous system P NETs.
Journal Article
Amplification of Multiple Genes from Chromosomal Region 12q13-14 in Human Malignant Gliomas: Preliminary Mapping of the Amplicons Shows Preferential Involvement of CDK4, SAS, and MDM2
TL;DR: CDK4, SAS, and MDM2 are suggested as main targets for the amplification of 9 different loci from 12q13-14 and the possibility exists that all amplicons share a common amplified region betweenMDM2 and CDK4/SAS which might contain one or more as yet unidentified genes.