Juliana Ide Aoki

TL;DR: Key aspects of lncRNA biology are reviewed, focusing on their role as regulatory elements in gene expression modulation during physiological and disease processes, with implications in host and pathogens physiology, and their role in immune response modulation.

TL;DR: The main aspects of Leishmania-host interaction are described, focusing on the arginine and polyamines pathways and pointing to possible targets to be used for prognosis and/or in the control of the infection.

TL;DR: Differential transcriptional profiling of amino acids transporters from La-WT and La-arg- promastigotes and axenic amastigote suggests that depending on the amino acid pool and arginase activity, Leishmania senses and could use an alternative route for the amino acids transport in response to stress signaling.

TL;DR: It is suggested that NOS-like is expressed in Leishmania in the stationary growth phase promastigotes and amastsigotes, and could be correlated to metacyclogenesis and amastigote growth in a dependent way to the internal pool of L-arginine and arginase activity.

TL;DR: L. amazonensis infection alters the TLR signaling pathways by modulating the expression of miRNAs in macrophages to subvert the host immune responses.