Juliane Vaxelaire

TL;DR: The induction of bone cancer in the rat by the syngeneic MRMT‐1 mammary tumour cell line provides a valid pre‐clinical model for pain associated with bone metastases and suggests a reasonable time window for evaluation of anti‐nociceptive agents between day 14 and 20 after cancer cell inoculation in this model.

TL;DR: It is observed that, in vivo, daily treatment of mice with doses of BKM120 up to 40 mg/kg led to tumor regressions with no increase in the mitotic index, indicating that strong antitumor activity can be achieved in PI3K-dependent models at exposures that are below those necessary to engage the off-target activity.

TL;DR: Patupilone (epothilone B), a highly potent non‐taxane microtubule stabilizing agent, was evaluated in models of androgen‐independent prostate cancer.

TL;DR: Combining patupilone with high-dose imatinib produced an increased antitumour effect without affecting the tolerability of treatment in a relatively chemoresistant rat C6 glioma model, and pooling the data from the two experiments confirmed a significant synergy for the combination.

TL;DR: Rabbits with established staphylococcal endocarditis, injected twice at an interval of 2 h with either 0.5 mg of cloxacillin per kg or saline, were sacrificed 2.5 h after the second injection, suggesting that antibiotic penetration from blood into vegetations and diffusion into fibrin were limited.