G
Glen Wotherspoon
Researcher at Novartis
Publications - 10
Citations - 2583
Glen Wotherspoon is an academic researcher from Novartis. The author has contributed to research in topics: Hyperalgesia & Allodynia. The author has an hindex of 10, co-authored 10 publications receiving 2461 citations.
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Journal ArticleDOI
Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain
Anna K. Clark,Ping K. Yip,John Grist,Clive Gentry,Amelia A. Staniland,Fabien Marchand,Maliheh Dehvari,Glen Wotherspoon,Janet Winter,Jakir Hussain Ullah,Stuart Bevan,Marzia Malcangio +11 more
TL;DR: It is suggested that under conditions of increased nociception, microglial CatS is responsible for the liberation of neuronal FKN, which stimulates p38 MAPK phosphorylation in microglia, thereby activating neurons via the release of pronociceptive mediators.
Journal ArticleDOI
siRNA relieves chronic neuropathic pain
Gabriele Dorn,Sadhana Patel,Glen Wotherspoon,Maja Hemmings-Mieszczak,Jane Barclay,Francois Natt,Pierre Martin,Stuart Bevan,Alyson Fox,Pam Ganju,William Leonard Wishart,Jonathan Hall +11 more
TL;DR: It is shown that RNAi can block a pathophysiological pain response and provide relief from neuropathic pain in a rat disease model by down regulating an endogenous, neuronally expressed gene.
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VR1 protein expression increases in undamaged DRG neurons after partial nerve injury.
TL;DR: Examination of the expression of the sensory neuron‐specific cation channel Vanilloid Receptor 1 (VR1), an important transducer of noxious stimuli, in three models of nerve injury in the rat found that VR1‐IR persisted in the transected sciatic nerve proximal to the lesion, despite its down‐regulation in the damaged neuronal somata.
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A rat model of bone cancer pain.
Stephen J. Medhurst,Katharine Walker,M Bowes,Bruce L. Kidd,Markus Glatt,Melanie Müller,Marc Hattenberger,Juliane Vaxelaire,Terence O'reilly,Glen Wotherspoon,Janet Winter,Jonathan Green,Laszlo Urban +12 more
TL;DR: The induction of bone cancer in the rat by the syngeneic MRMT‐1 mammary tumour cell line provides a valid pre‐clinical model for pain associated with bone metastases and suggests a reasonable time window for evaluation of anti‐nociceptive agents between day 14 and 20 after cancer cell inoculation in this model.
Journal ArticleDOI
Functional Downregulation of P2X3 Receptor Subunit in Rat Sensory Neurons Reveals a Significant Role in Chronic Neuropathic and Inflammatory Pain
Jane Barclay,Sadhana Patel,Gabriele Dorn,Glen Wotherspoon,Sarah Moffatt,L. H. Eunson,Samir Abdel'Al,Francois Natt,Jonathan Hall,Janet Winter,Stuart Bevan,William Leonard Wishart,Alyson Fox,Pam Ganju +13 more
TL;DR: The utility of ASO approaches for validating gene targets in in vivo pain models and evidence for a role of P2X3 receptors in the pathophysiology of chronic pain are provided.