Showing papers by "Julie A. Dumas published in 2022"
TL;DR: It is suggested that greater levels of cognitive complaints following menopause may be associated with an underlying decline in cholinergic function that may manifest as an inability to compensate during working memory tasks.
Abstract: Older women are at increased risk of developing Alzheimer's disease compared to men. One proposed reason is that following menopause there is a decline in estrogens. Estrogens are important for cholinergic functioning and attenuate the impact of cholinergic antagonists on cognitive performance in postmenopausal women. Self‐reported or subjective cognitive complaints in middle or older age may represent a harbinger of cognitive decline and those who endorse cognitive complaints appear more likely to develop future cognitive impairment. However, the response of individuals with cognitive complaints after menopause to estrogen and the relationship to cholinergic functioning has not been investigated. This study investigated the effect of estrogen treatment using 17β‐estradiol on cognitive performance following anticholinergic blockade in postmenopausal women and the relationship of this interaction with the level of self‐reported (subjective) postmenopausal cognitive complaints.
1 citations
TL;DR: The potential links between a history of preeclampsia and the development of dementia are examined and how hypertensive disorders of pregnancy may relate to both normal brain aging and dementia is discussed to highlight the need for additional research regarding the long-term cognitive effects of preeClampsia on the brain.
Abstract: The development of preeclampsia during pregnancy may have long-term effects on brain aging in women. Associations between preeclampsia and vascular dementia have been established, however the connection between preeclampsia and Alzheimer’s disease has not been as thoroughly explored. Both preeclampsia and Alzheimer’s disease have been associated with misfolded amyloid beta proteins and inflammation; due to these similarities, in this minireview, we examined the potential links between a history of preeclampsia and the development of dementia. We also discussed how hypertensive disorders of pregnancy may relate to both normal brain aging and dementia to highlight the need for additional research regarding the long-term cognitive effects of preeclampsia on the brain.
1 citations
01 Dec 2022
TL;DR: In this paper , the authors investigated cholinergic system integrity in a sample of cognitively normal postmenopausal women, aged 50−70 years, that were part of a larger study examining choline compensation following menopause, and predicted that higher FEOBV standardized uptake value ratios (SUVR) would be associated with larger basal forebrain choline volumes, lower levels of amyloid SUVR, and better cognitive performance.
Abstract: Women are at a higher risk of developing Alzheimer’s disease (AD), and a possible reason for this may be the effects of estrogen depletion and cholinergic system activity following menopause. The investigational radiotracer [18F]‐fluoroethoxybenzovesamicol (FEOBV) can assess in vivo cholinergic integrity, as the tracer binds to the vesicular cholinergic transporter at the synapse. FEOBV has previously shown cholinergic system decline in AD patients. The present study is an investigation of cholinergic system integrity in a sample of cognitively normal postmenopausal women, aged 50‐70 years that were part of a larger study examining cholinergic compensation following menopause. We predicted that higher FEOBV standardized uptake value ratios (SUVR) would be associated with larger basal forebrain cholinergic volumes, lower levels of amyloid SUVR, and better cognitive performance as measured by the RBANS.
TL;DR: In this article , the authors correct the article DOI: 10.3389/fphys.2022.979547 and 10.3489/Fphys.1922.
Abstract: [This corrects the article DOI: 10.3389/fphys.2022.979547.].