Julio Benítez

TL;DR: The results confirm the fact that phenothiazines, and to a lesser extent haloperidol, inhibit the oxidative metabolism of debrisoquine and show also that clothiapine administration does not disturb the debrisquine metabolic ratio.

TL;DR: The combined effect of environmental toxins and CYP2D6 in the cause of Parkinson's disease is suggested, indicating that the oxidative polymorphism is related to early‐onset but not to late-onset Parkinson's Disease.

TL;DR: The genetic polymorphism of NAT2 is a relevant factor in the risk for developing HCC (inverse odds ratio slow vs rapid = 1.8; 95% CI 1.1-3.0) and the additional determination of alleles of the cytochrome P450 2D6 (CYP2D6) gene in the same subjects confirmed the previous findings that subjects with two active CYP2D 6 genes are at increased risk of developing H CC.

TL;DR: The presence of CYP1A2, CYP2C9, CyP2D6 and CYP3A in brain, as well as the possible existence of local brain metabolism, are reviewed and the putative implications of endogenous modulation of these isoenzymes by neurotransmitters are discussed.

TL;DR: The presence of carcinogen-metabolizing enzymes in human prostate with a high interindividual variability may be involved in the regulation of local levels of carcinogens and mutagens and may underlie interindividual differences in cancer susceptibility.