J
Julio Benítez
Researcher at University of Extremadura
Publications - 108
Citations - 4483
Julio Benítez is an academic researcher from University of Extremadura. The author has contributed to research in topics: Debrisoquine & Genotype. The author has an hindex of 40, co-authored 108 publications receiving 4357 citations. Previous affiliations of Julio Benítez include University of Illinois at Urbana–Champaign & Hospital Clínico San Carlos.
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Journal ArticleDOI
Relationship between personality and debrisoquine hydroxylation capacity. Suggestion of an endogenous neuroactive substrate or product of the cytochrome P4502D6.
TL;DR: There may be a relationship between personality and the activity of the enzyme hydroxylating debrisoquine (cytochrome P4502D6), which may have an endogenous neuroactive substrate or product, such as a biogenic neurotransmitter amine.
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Evaluation of caffeine as an in vivo probe for CYP1A2 using measurements in plasma, saliva, and urine.
Juan Antonio Carrillo,Magnus Christensen,Sara I. Ramos,Christina Alm,Marja-Liisa Dahl,Julio Benítez,Leif Bertilsson +6 more
TL;DR: Among caffeine-based approaches for CYP1A2, the authors recommend either plasma or saliva 17X/ 137X ratio and the urinary (AFMU + 1U + 1X + 17U + 17X)/137X ratio during a sampling interval of at least 8 hours, starting at time zero since caffeine intake.
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Comparative in vitro and in vivo inhibition of cytochrome P450 CYP1A2, CYP2D6, and CYP3A by H2-receptor antagonists.
Carmen Martínez,Carlos Albet,José A. G. Agúndez,Eduardo Herrero,Juan Antonio Carrillo,Miguel A. Márquez,Julio Benítez,José Alfonso Ortiz +7 more
TL;DR: Patients who are receiving treatment with drugs metabolized through CYP3A may experience enhanced drug effects as a result of pharmacokinetic interaction when treated concomitantly with cimetidine, in contrast, the effect of ranitidine or ebrotidine on CYP 3A activity in vivo seems to have little clinical significance.
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CYP1A2 activity, gender and smoking, as variables influencing the toxicity of caffeine.
TL;DR: It is concluded that CYP1A2 activity, gender and smoking are variables to be considered as influencing the toxicity of caffeine.
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Interethnic differences in drug metabolism: influence of genetic and environmental factors on debrisoquine hydroxylation phenotype.
TL;DR: It is suggested that debrisoquine MR may be modified by tobacco smoking and sexual hormones, and partly responsible for the variations in haloperidol disposition between races.