J
Jun Zhang
Researcher at Second Military Medical University
Publications - 13
Citations - 385
Jun Zhang is an academic researcher from Second Military Medical University. The author has contributed to research in topics: Triazole & Fluconazole. The author has an hindex of 11, co-authored 13 publications receiving 349 citations.
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Journal ArticleDOI
Design, synthesis and antifungal activities of novel 1,2,4-triazole derivatives.
Jian-Ming Xu,Yong-Bing Cao,Jun Zhang,Shichong Yu,Yan Zou,Xiaoyun Chai,Qiuye Wu,Dazhi Zhang,Yuan-Ying Jiang,Qingyan Sun +9 more
TL;DR: A series of novel 1,2,4-triazole derivatives with a 4-(4-substitutedphenyl) piperazine side chain were designed and synthesized based on the structure of lanosterol 14α-demethylase (CYP51) and found to be more potent against Candida albicans than control drug fluconazole.
Journal ArticleDOI
Synthesis of novel triazole derivatives as inhibitors of cytochrome P450 14α-demethylase (CYP51)
Qingyan Sun,Jian-Ming Xu,Yong-Bing Cao,Wannian Zhang,Qiuye Wu,Dazhi Zhang,Jun Zhang,Hui-Qing Zhao,Yuan-Ying Jiang +8 more
TL;DR: Results of preliminary antifungal tests against eight human pathogenic fungi in vitro showed that all title compounds exhibited activity against fungi tested to some extent.
Journal ArticleDOI
Design, synthesis, and biological evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14α-demethylase
Xiaoyun Chai,Jun Zhang,Honggang Hu,Shichong Yu,Qingyan Sun,Zhigang Dan,Yuanying Jiang,Qiuye Wu +7 more
TL;DR: Based on the results of computational docking to the active site of the cytochrome P450 14alpha-demethylase (CYP51), a series of 1-(1H-1,2,4-triazole-1-yl)-2-(2, 4-difluorophenyl)-3-substituted-2-propanols as analogs of fluconazole were designed, synthesized, and evaluated as antifungal agents.
Journal ArticleDOI
Synthesis, in vitro evaluation and molecular docking studies of new triazole derivatives as antifungal agents
Yongwei Jiang,Jun Zhang,Yong-Bing Cao,Xiaoyun Chai,Yan Zou,Qiuye Wu,Dazhi Zhang,Yuan-Ying Jiang,Qingyan Sun +8 more
TL;DR: Results of the preliminary antifungal tests against eight human pathogenic fungi in vitro showed that these compounds exhibited activities to some extent, and some displayed excellent antIFungal activities against C. albicans than reference drug fluconazole.
Journal ArticleDOI
Design, synthesis, and biological evaluation of novel 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted benzylamino-2-propanols.
Xiaoyun Chai,Jun Zhang,Shichong Yu,Honggang Hu,Yan Zou,Qingjie Zhao,Zhigang Dan,Dazhi Zhang,Qiuye Wu +8 more
TL;DR: Preliminary antifungal tests against eight human pathogenic fungi in vitro showed that all the title compounds exhibited excellent activities with broad spectrum.