J
Jun Zhang
Researcher at University of Louisville
Publications - 20
Citations - 3084
Jun Zhang is an academic researcher from University of Louisville. The author has contributed to research in topics: Protein kinase C & Protein Kinase C-epsilon. The author has an hindex of 16, co-authored 19 publications receiving 3046 citations.
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Journal ArticleDOI
Ischemic Preconditioning Induces Selective Translocation of Protein Kinase C Isoforms ε and η in the Heart of Conscious Rabbits Without Subcellular Redistribution of Total Protein Kinase C Activity
Peipei Ping,Jun Zhang,Yumin Qiu,Xian-Liang Tang,Srinivas Manchikalapudi,Xinan Cao,Roberto Bolli +6 more
TL;DR: Quantitative immunoblotting demonstrated that as a subgroup, conventional PKCs are more abundant than novel PKCs (nPKCs) and that PKC alpha is the predominant isoform among the cPKCs (alpha, beta1, beta2, and gamma), representing 51% of this sub group, and PKC epsilon is the most abundant among the nPKCs
Journal ArticleDOI
Mitochondrial PKCε and MAPK Form Signaling Modules in the Murine Heart Enhanced Mitochondrial PKCε-MAPK Interactions and Differential MAPK Activation in PKCε-Induced Cardioprotection
Christopher P. Baines,Jun Zhang,Guang Wu Wang,Yu Ting Zheng,Joanne X. Xiu,Ernest M. Cardwell,Roberto Bolli,Peipei Ping +7 more
TL;DR: Together, data show that PKCepsilon forms subcellular-targeted signaling modules with ERKs, leading to the activation of mitochondrialERKs.
Journal ArticleDOI
The nitric oxide hypothesis of late preconditioning.
Roberto Bolli,Buddhadeb Dawn,Xian-Liang Tang,Yumin Qiu,Peipei Ping,Yu-Ting Xuan,W.K. Jones,Hitoshi Takano,Yiru Guo,Jun Zhang +9 more
TL;DR: The NO hypothesis of late PC puts forth a comprehensive paradigm that can explain both the initiation and the mediation of this complex phenomenon, and has potential clinical reverberations, since NO donors are widely used clinically and could be used to protect the ischemic myocardium in patients.
Journal ArticleDOI
Isoform-Selective Activation of Protein Kinase C by Nitric Oxide in the Heart of Conscious Rabbits A Signaling Mechanism for Both Nitric Oxide–Induced and Ischemia-Induced Preconditioning
Peipei Ping,Hitoshi Takano,Jun Zhang,Xian Liang Tang,Yumin Qiu,Richard C. Li,Supratim Banerjee,Buddhadeb Dawn,Zarema Balafonova,Roberto Bolli +9 more
TL;DR: The results provide direct evidence that NO donors induce late PC by activating PKC and that among the 10 isozymes of PKC expressed in the rabbit heart, the epsilon isotype is specifically involved in the development of this form of pharmacological PC.
Journal ArticleDOI
Functional Proteomic Analysis of Protein Kinase C ε Signaling Complexes in the Normal Heart and During Cardioprotection
TL;DR: Using two-dimensional electrophoresis, mass spectrometry, immunoblotting, and affinity pull-down assays, it is found that myocardial protein kinase C &egr; (PKC&egr) is physically associated with at least 36 known proteins that are organized into structural proteins, signaling molecules, and stress-responsive proteins.