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Yu-Ting Xuan
Researcher at University of Kansas
Publications - 44
Citations - 4808
Yu-Ting Xuan is an academic researcher from University of Kansas. The author has contributed to research in topics: Ischemic preconditioning & Nitric oxide synthase. The author has an hindex of 35, co-authored 43 publications receiving 4509 citations. Previous affiliations of Yu-Ting Xuan include Jewish Hospital & University of Louisville.
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Journal ArticleDOI
Cyclooxygenase-2 mediates the cardioprotective effects of the late phase of ischemic preconditioning in conscious rabbits
Ken Shinmura,Xian Liang Tang,Yang Wang,Yu-Ting Xuan,Siqi Liu,Hitoshi Takano,Aruni Bhatnagar,Roberto Bolli +7 more
TL;DR: Results demonstrate that, in conscious rabbits, up-regulation of COX-2 plays an essential role in the cardioprotection afforded by the late phase of ischemic PC.
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Nuclear Factor-κB Plays an Essential Role in the Late Phase of Ischemic Preconditioning in Conscious Rabbits
Yu-Ting Xuan,Xian Liang Tang,Supratim Banerjee,Hitoshi Takano,Richard C. Li,Hui Han,Yumin Qiu,Jian Jun Li,Roberto Bolli +8 more
TL;DR: This is the first demonstration that NO can promote NF-kappaB activation in the heart, a finding that identifies a new biological function of NO and may have important implications for various pathophysiological conditions in which NO is involved and for nitrate therapy.
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An essential role of the JAK-STAT pathway in ischemic preconditioning.
TL;DR: It is demonstrated that ischemic PC induces isoform-selective activation of JAK1, JAK2, STAT1, and STAT3, and that ablation of this response impedes the up-regulation of iNOS and the concurrent acquisition of isChemic tolerance.
Journal ArticleDOI
The nitric oxide hypothesis of late preconditioning.
Roberto Bolli,Buddhadeb Dawn,Xian-Liang Tang,Yumin Qiu,Peipei Ping,Yu-Ting Xuan,W.K. Jones,Hitoshi Takano,Yiru Guo,Jun Zhang +9 more
TL;DR: The NO hypothesis of late PC puts forth a comprehensive paradigm that can explain both the initiation and the mediation of this complex phenomenon, and has potential clinical reverberations, since NO donors are widely used clinically and could be used to protect the ischemic myocardium in patients.
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Divergent Tumor Necrosis Factor Receptor–Related Remodeling Responses in Heart Failure Role of Nuclear Factor-κB and Inflammatory Activation
Tariq Hamid,Yan Gu,Roger V. Ortines,Chhandashri Bhattacharya,Guangwu Wang,Yu-Ting Xuan,Sumanth D. Prabhu +6 more
TL;DR: In this article, the authors hypothesized that TNF induces opposing inflammatory and remodeling responses in heart failure that are TNF-receptor (TNFR) specific, and they showed that 4-week post-infarction survival was significantly improved in both TNFR1−/− and TNFR2−/+ mice.