J
Junping Li
Researcher at University of South Carolina
Publications - 17
Citations - 1133
Junping Li is an academic researcher from University of South Carolina. The author has contributed to research in topics: Trabecular meshwork & Basic fibroblast growth factor. The author has an hindex of 11, co-authored 17 publications receiving 1064 citations.
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Journal ArticleDOI
Aqueous Humor in Glaucomatous Eyes Contains an Increased Level of TGF-β2
TL;DR: The present findings support the concept of the intraocular derivation of this cytokine and hypothesize that the increased level of TGF-β2 in the aqueous humor of POAG patients causes a decrease in the cellularity of the trabecular meshwork and promotes the buildup of excessive amounts of ECM materials that are characteristic of this disease and contribute to the increased resistance to aQueous outflow.
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Increased level of vascular endothelial growth factor in aqueous humor of patients with neovascular glaucoma.
TL;DR: The authors' findings show that patients with NVG had a significantly increased level of VEGF in the aqueous humor and implicate V EGF as an important factor in the pathogenesis of intraocular neovascularization in these patients.
Journal ArticleDOI
Trabecular Cells Express the TGF-β2 Gene and Secrete the Cytokine
TL;DR: It is hypothesized that abnormal changes in the production of TGF-beta s by trabecular cells and/or in the activation of these growth modulators contribute to the excess accumulation of extracellular matrix components in the aqueous outflow system as observed in aging and glaucomatous eyes.
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Growth factors in the aqueous humor and their clinical significance.
Journal Article
Modulation of pre-mRNA splicing and protein production of fibronectin by TGF-beta2 in porcine trabecular cells.
TL;DR: A mechanism whereby TGF-beta2, the concentration of which is elevated in aqueous humor of patients with primary open-angle glaucoma, contributes to the increased deposition of extracellular matrix molecules in the outflow pathway is indicated.