J
Jürgen M. Schmidt
Researcher at University of Kent
Publications - 27
Citations - 1120
Jürgen M. Schmidt is an academic researcher from University of Kent. The author has contributed to research in topics: Virus & Hepatitis C virus. The author has an hindex of 14, co-authored 27 publications receiving 1105 citations. Previous affiliations of Jürgen M. Schmidt include Goethe University Frankfurt.
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Journal ArticleDOI
Effect of interferon alfa on the dynamics of hepatitis C virus turnover in vivo
TL;DR: The half life data for HCV in chronically infected patients are remarkably similar to recently published data on human immunodeficiency virus type 1 (HIV‐1), suggesting that both RNA viruses replicate continuously and highly productive in vivo.
Journal ArticleDOI
Hepatitis C virus dynamics in vivo: effect of ribavirin and interferon alfa on viral turnover.
Stefan Zeuzem,Jürgen M. Schmidt,Jung-Hun Lee,Michael von Wagner,Gerlinde Teuber,W. Kurt Roth +5 more
TL;DR: The data of the present study indicate that higher rIFN‐α doses accelerate viral clearance from serum, and ribavirin lacks synergistic antiviral effects in the treatment of chronic hepatitis C with 3 × 6 MU rIFn‐α per week.
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Dynamics of hepatitis B virus infection in vivo
TL;DR: The half-life of HBV in chronically infected patients is longer and in vivo turnover rates are higher compared to recently published data on the human immunodeficiency virus type 1 and the hepatitis C virus.
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Hepatitis C Virus Kinetics
TL;DR: The balance of virus production and clearance for untreated patients with chronic hepatitis C virus (HCV) results in a decline of viraemia when initiating active antiviral treatment.
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Self-consistent 3J coupling analysis for the joint calibration of Karplus coefficients and evaluation of torsion angles.
TL;DR: Application to the protein Desulfovibrio vulgaris flavodoxin demonstrates the simultaneous refinement of torsion-angle values and related Karplus coefficients, which are applicable to the conformational analysis of φ torsions in other polypeptides.