J
Justin Chapman
Publications - 3
Citations - 33
Justin Chapman is an academic researcher. The author has contributed to research in topics: Transthyretin & Proteotoxicity. The author has an hindex of 2, co-authored 3 publications receiving 30 citations.
Papers
More filters
Journal ArticleDOI
Cellular clearance of circulating transthyretin decreases cell-nonautonomous proteotoxicity in Caenorhabditis elegans.
Kayalvizhi Madhivanan,Erin R. Greiner,Miguel Alves-Ferreira,Miguel Alves-Ferreira,David Soriano-Castell,Nirvan Rouzbeh,Carlos A. Aguirre,Johan Paulsson,Justin Chapman,Xin Jiang,Felicia K. Ooi,Carolina Lemos,Andrew Dillin,Andrew Dillin,Veena Prahlad,Jeffery W. Kelly,Sandra E. Encalada +16 more
TL;DR: Animal models of the transthyretin (TTR) amyloidoses are generated and characterized that faithfully recapitulate cell-nonautonomous neuronal proteotoxicity by expressing human TTR in the Caenorhabditis elegans muscle, revealing a critical role for trans modulation of aggregation-prone degradation that directly affects postmitotic tissue degeneration observed in the proteinopathies.
Patent
Transthyretin antibodies and uses thereof
TL;DR: In this article, the authors provide compositions comprising anti-transthyretin antibodies for diagnosis, prognosis and/or treatment of amyloid diseases or symptoms thereof.
Patent
Anticorps anti-transthyrétine et leurs utilisations
TL;DR: In this article, the authors present a set of compositions comportant des anticorps anti-transthyretine, which are particulierement utiles for le diagnostic, le pronostic et/ou le traitement de maladies amyloides ou de symptomes de celles-ci.