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Andrew Dillin
Researcher at University of California, Berkeley
Publications - 168
Citations - 24437
Andrew Dillin is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Proteostasis & Unfolded protein response. The author has an hindex of 62, co-authored 154 publications receiving 20922 citations. Previous affiliations of Andrew Dillin include Salk Institute for Biological Studies & California Institute for Regenerative Medicine.
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Journal ArticleDOI
Adapting proteostasis for disease intervention.
TL;DR: The proteostasis network is described, a set of interacting activities that maintain the health of proteome and the organism that has the potential to ameliorate some of the most challenging diseases of this era.
Journal ArticleDOI
Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
Daniel F. Egan,David B. Shackelford,Maria M. Mihaylova,Sara Gelino,Rebecca A. Kohnz,William B. Mair,Debbie S. Vasquez,Aashish Joshi,Dana M. Gwinn,Rebecca C. Taylor,John M. Asara,James A. J. Fitzpatrick,Andrew Dillin,Benoit Viollet,Mondira Kundu,Malene Hansen,Reuben J. Shaw +16 more
TL;DR: Reconstitution of ULK1-deficient cells with a mutant ULK2 that cannot be phosphorylated by AMPK revealed that such phosphorylation is required for mitochondrial homeostasis and cell survival during starvation.
Journal ArticleDOI
ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase
Ryan C. Russell,Ye Tian,Hai-Xin Yuan,Hyun Woo Park,Yu Yun Chang,Joungmok Kim,Joungmok Kim,Haerin Kim,Thomas P. Neufeld,Andrew Dillin,Kun-Liang Guan +10 more
TL;DR: A molecular mechanism linking ULK to the pro-autophagic lipid kinase VPS34 is described, whereby the activated ULK1 phosphorylates Beclin-1 on Ser 14, thereby enhancing the activity of the ATG14L-containing V PS34 complexes.
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Biological and Chemical Approaches to Diseases of Proteostasis Deficiency
TL;DR: It is proposed that small molecules can enhance proteostasis by binding to and stabilizing specific proteins (pharmacologic chaperones) or by increasing the protestasis network capacity (proteostasis regulators) and that such therapeutic strategies, including combination therapies, represent a new approach for treating a range of diverse human maladies.
Journal ArticleDOI
Rates of Behavior and Aging Specified by Mitochondrial Function During Development
Andrew Dillin,Ao Lin Hsu,Nuno Arantes-Oliveira,Joshua E. Lehrer-Graiwer,Honor Hsin,Honor Hsin,Andrew G. Fraser,Ravi S. Kamath,Julie Ahringer,Cynthia Kenyon +9 more
TL;DR: The developing animal appears to contain a regulatory system that monitors mitochondrial activity early in life and, in response, establishes rates of respiration, behavior, and aging that persist during adulthood.