Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.

Methods and apparatus for renal neuromodulation

An apparatus comprising a deformable lens element can be provided wherein a deformable lens element can be deformed to change an optical property thereof by the impartation of a force to the deformable lens element.

Apparatus and method comprising deformable lens element

A catheter and catheter system can use energy tailored for remodeling and/or removal of target material along a body lumen, often of atherosclerotic material of a blood vessel of a patient. An elongate flexible catheter body with a radially expandable structure may have a plurality of electrodes or other electrosurgical energy delivery surfaces to radially engage atherosclerotic material when the structure expands. An atherosclerotic material detector system may measure and/or characterize the atherosclerotic material and its location, optionally using impedance monitoring.

Tuned rf energy and electrical tissue characterization for selective treatment of target tissues

Systems and methods for making and using handheld data readers comprising one or more fluid lenses. One or more fluid lenses are provided to allow a handheld data reader to perform such operations as reading indicia, including such additional operations as zooming, reorienting a viewing direction, focusing, adjusting an optical axis, and correcting for the effects of motion such as hand jitter. The fluid lens or lenses can be operated for example by applying electrical signals to fluid lenses comprising a plurality of fluids including at least one that is conductive and at least one that is non-conductive.

Data reader apparatus having an adaptive lens

A package with an integral window for housing a microelectronic device. The integral window is bonded directly to the package without having a separate layer of adhesive material disposed in-between the window and the package. The device can be a semiconductor chip, CCD chip, CMOS chip, VCSEL chip, laser diode, MEMS device, or IMEMS device. The package can be formed of a multilayered LTCC or HTCC cofired ceramic material, with the integral window being simultaneously joined to the package during cofiring. The microelectronic device can be flip-chip interconnected so that the light-sensitive side is optically accessible through the window. A glob-top encapsulant or protective cover can be used to protect the microelectronic device and electrical interconnections. The result is a compact, low profile package having an integral window that is hermetically sealed to the package prior to mounting and interconnecting the microelectronic device.

Single level microelectronic device package with an integral window

A fluidic optical device, systems utilizing fluidic optical devices, methods for manufacturing fluidic optical devices and actuators are disclosed.

Fluidic optical devices

We examine wave-front distortion caused by high-power lasers on transmissive optics using a Shack-Hartmann wave-front sensor. The coupling coefficient for a thermally aberrated Gaussian beam to the TEM(00) mode of a cavity was determined as a function of magnitude of the thermally induced aberration. One wave of thermally induced phase aberration between the Gaussian intensity peak and the 1/e(2) radius of the intensity profile reduces the power-coupling coefficient to the TEM(00) mode of the cavity to 4.5% with no compensation. With optimal focus compensation the power coupling is increased to 79%. The theoretical shape of the thermally induced optical phase aberration is compared with measurements made in a neutral-density filter glass, Faraday glass, and lithium niobate. The agreement between the theoretical and the measured thermal aberration profiles is within the rms wave-front measurement sensitivity of the Shack-Hartmann wave-front sensor, which is a few nanometers.

/pdf/evaluating-the-effect-of-transmissive-optic-thermal-lensing-14vmemod46.pdf

Evaluating the effect of transmissive optic thermal lensing on laser beam quality with a shack-hartmann wave-front sensor.

An electrostatically actuated fluidic device capable of providing a variable focal length lens is disclosed. The device includes an elastic capacitor section, an elastic lens section in fluid communication with the capacitor section, the elastic lens section being characterized by a focal length and a fluid capable of fluid motion disposed at least partially in the capacitor and lens sections. A voltage may be applied to the capacitor section causing it to deform, which causes a portion of the fluid to flow into or out of the lens section. As a result, a change in volume of fluid in the lens section causes it to deform resulting in a variation in the focal length of the lens section.

Fluidic lens with electrostatic actuation

A Shack-Hartmann wavefront sensor having an aperture which is smaller than the size of an object being measured is used to measure the wavefront for the entire object. The wavefront sensor and object are translated relative to one another to measure the wavefronts at a plurality of subregions of the object. The measured wavefronts are then stitched together to form a wavefront of the object. The subregions may overlap in at least one dimension. A reference surface may be provided to calibrate the wavefront sensor.

Apparatus and method for evaluating a target larger than a measuring aperture of a sensor

We report a novel, miniature Fourier transform spectrometer with a linear architecture that works by sampling a standing wave. The spectrometer consists of an electrostatically actuated microelectromechanical mirror with on-resonance displacement of up to 65 /spl mu/m, a thin-film photodetector, and an electrical back plane for actuating the mirror. The integrated device offers mirror stability and fixed relative alignment of the three components. The spectrometer has better than 32-nm resolution at 633 nm.

/pdf/standing-wave-fourier-transform-spectrometer-based-on-3jv3emc546.pdf

Justin D. Mansell

Papers

Fluidic optical devices

Evaluating the effect of transmissive optic thermal lensing on laser beam quality with a shack-hartmann wave-front sensor.

Fluidic lens with electrostatic actuation

Apparatus and method for evaluating a target larger than a measuring aperture of a sensor

Standing-wave Fourier transform spectrometer based on integrated MEMS mirror and thin-film photodetector