J
Jyoti Chattopadhyaya
Researcher at Uppsala University
Publications - 400
Citations - 7277
Jyoti Chattopadhyaya is an academic researcher from Uppsala University. The author has contributed to research in topics: Nuclear magnetic resonance spectroscopy & Oligonucleotide. The author has an hindex of 39, co-authored 400 publications receiving 7096 citations. Previous affiliations of Jyoti Chattopadhyaya include Ochanomizu University & University of Cambridge.
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Journal ArticleDOI
How do the gauche and anomeric effects drive the pseudorotational equilibrium of the pentofuranose moiety of nucleosides
TL;DR: In this paper, the van't Hoff plots of (In(&/&)) as a function of 1 / Tgave AH' and AS' values of pseudorotational equilibrium in pentofuranoses and ribo-@-D-nucleosides (Ade (12), Gua (13), Cyt (14)) were established through the analysis of vicinal proton-proton coupling constants extracted from their 500-MHz lH-NMR spectra recorded at 20 K intervals in the temperature range from 278 to 358 K in D20 solution
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Allele-selective inhibition of mutant huntingtin expression with antisense oligonucleotides targeting the expanded CAG repeat.
Keith T. Gagnon,Hannah Pendergraff,Glen F. Deleavey,Eric E. Swayze,Pierre Potier,John Randolph,Eric B. Roesch,Jyoti Chattopadhyaya,Masad J. Damha,C. Frank Bennett,Christophe Montaillier,Marc M. Lemaitre,David R. Corey +12 more
TL;DR: ASOs targeted to the CAG repeat of HTT provide a starting point for the development of oligonucleotide-based therapeutics that can inhibit gene expression with allelic discrimination in patients with HD.
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Structure and toxicity of a peptide hepatotoxin from the cyanobacterium Oscillatoria agardhii.
TL;DR: The structural and toxic properties of this peptide are very close to those of microcystins, cyclic peptide toxins produced by the cyanobacterium Microcystis aeruginosa.
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Five- and Six-Membered Conformationally Locked 2',4'-Carbocyclic ribo-Thymidines: Synthesis, Structure, and Biochemical Studies
Puneet Srivastava,Jharna Barman,Wimal Pathmasiri,Oleksandr Plashkevych,Małgorzata Wenska,Jyoti Chattopadhyaya +5 more
TL;DR: Clearly, remarkably enhanced lifetimes of these carbocyclic-modified AONs in the blood serum may produce the highly desired pharmacokinetic properties because of their unique stability and consequently a net reduction of the required dosage.
Journal ArticleDOI
Fine tuning of electrostatics around the internucleotidic phosphate through incorporation of modified 2',4'-carbocyclic-LNAs and -ENAs leads to significant modulation of antisense properties.
Chuanzheng Zhou,Yi Liu,Mounir Andaloussi,Naresh Badgujar,Oleksandr Plashkevych,Jyoti Chattopadhyaya +5 more
TL;DR: It is shown here how the fine adjustment of the electrostatic interaction by alteration of the substituents as well as their stereochemical environment around the internucleotidic phosphodiester moiety near the edge of the minor grove of the antisense oligonucleotides (AON)-RNA heteroduplex can lead to the modulation of theantisense properties.