J
Jyoti D. Malhotra
Researcher at University of Michigan
Publications - 27
Citations - 5979
Jyoti D. Malhotra is an academic researcher from University of Michigan. The author has contributed to research in topics: Endoplasmic reticulum & Sodium channel. The author has an hindex of 22, co-authored 26 publications receiving 5510 citations. Previous affiliations of Jyoti D. Malhotra include Columbia University.
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Journal ArticleDOI
Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword?
TL;DR: Persistent oxidative stress and protein misfolding initiate apoptotic cascades and are now known to play predominant roles in the pathogenesis of multiple human diseases including diabetes, atherosclerosis, and neurodegenerative diseases.
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The endoplasmic reticulum and the unfolded protein response.
TL;DR: The endoplasmic reticulum is the site where proteins enter the secretory pathway, and those processes that prevent accumulation of unfolded proteins in the ER lumen are highly regulated by an intracellular signaling pathway known as the unfolded protein response (UPR).
Journal ArticleDOI
Antioxidants reduce endoplasmic reticulum stress and improve protein secretion
Jyoti D. Malhotra,Hongzhi Miao,Kezhong Zhang,Anna R. Wolfson,Subramaniam Pennathur,Steven W. Pipe,Randal J. Kaufman +6 more
TL;DR: The findings indicate that reactive oxygen species are a signal generated by misfolded protein in the ER that cause UPR activation and cell death and may provide an avenue to treat and/or prevent diseases of protein misfolding.
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The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis
Kezhong Zhang,Kezhong Zhang,Shiyu Wang,Jyoti D. Malhotra,Justin R. Hassler,Sung Hoon Back,Guohui Wang,Lin Chang,Wenbo Xu,Hongzhi Miao,Roberta Leonardi,Y. Eugene Chen,Suzanne Jackowski,Randal J. Kaufman +13 more
TL;DR: The identification of IRE1α as a key regulator to prevent hepatic steatosis provides novel insights into ER stress mechanisms in fatty liver diseases associated with toxic liver injuries.
Journal ArticleDOI
ER Stress and Its Functional Link to Mitochondria: Role in Cell Survival and Death
TL;DR: The signaling/communication between the ER and mitochondria is discussed and the role of the mitochondrial permeability transition pore in these complex processes is focused on, which provides an adaptive mechanism by which cells can augment protein folding and processing capacities of the ER.