S
Sung Hoon Back
Researcher at University of Ulsan
Publications - 47
Citations - 6377
Sung Hoon Back is an academic researcher from University of Ulsan. The author has contributed to research in topics: Unfolded protein response & Endoplasmic reticulum. The author has an hindex of 22, co-authored 45 publications receiving 5476 citations. Previous affiliations of Sung Hoon Back include University of Michigan.
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Journal ArticleDOI
ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death
Jaeseok Han,Sung Hoon Back,Junguk Hur,Yu Hsuan Lin,Robert D. Gildersleeve,Jixiu Shan,Celvie L. Yuan,Dawid Krokowski,Shiyu Wang,Maria Hatzoglou,Michael S. Kilberg,Maureen A. Sartor,Randal J. Kaufman +12 more
TL;DR: It is shown that eIF2α-phosphorylation-attenuated protein synthesis, and not Atf4 mRNA translation, promotes cell survival, and suggesting that limiting protein synthesis will be therapeutic for diseases caused by protein misfolding in the ER.
Journal ArticleDOI
Endoplasmic Reticulum Stress Activates Cleavage of CREBH to Induce a Systemic Inflammatory Response
Kezhong Zhang,Xiaohua Shen,Jun Wu,Kenjiro Sakaki,Thomas L. Saunders,D. Thomas Rutkowski,Sung Hoon Back,Randal J. Kaufman +7 more
TL;DR: The studies delineate a molecular mechanism for activation of an ER-localized transcription factor, CREBH, and reveal an unprecedented link by which ER stress initiates an acute inflammatory response.
Journal ArticleDOI
Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine
Kook Hwan Kim,Yeon Taek Jeong,Hyunhee Oh,Seonghun Kim,Jae Min Cho,Yo-Na Kim,Su Sung Kim,Dohoon Kim,Kyu Yeon Hur,Hyoung Kyu Kim,Tae-Hee Ko,Jin Han,Hong Lim Kim,Jin Kim,Sung Hoon Back,Masaaki Komatsu,Hsiuchen Chen,David C. Chan,Morichika Konishi,Nobuyuki Itoh,Cheol Soo Choi,Myung-Shik Lee,Myung-Shik Lee +22 more
TL;DR: It is suggested that autophagy deficiency and subsequent mitochondrial dysfunction promote Fgf21 expression, a hormone the authors consequently term a 'mitokine', and together these processes promote protection from diet-induced obesity and insulin resistance.
Journal ArticleDOI
UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators
D. Thomas Rutkowski,Jun Wu,Sung Hoon Back,Michael U. Callaghan,Michael U. Callaghan,Sean P. Ferris,Jahangir Iqbal,Robert Clark,Hongzhi Miao,Justin R. Hassler,Jamie L. Fornek,Michael G. Katze,M. Mahmood Hussain,Benbo Song,Jayanth Swathirajan,Junying Wang,Grace D.-Y. Yau,Randal J. Kaufman +17 more
TL;DR: An unanticipated direct link between ER homeostasis and the transcriptional regulation of metabolism is revealed, and mechanisms by which ER stress might underlie fatty liver disease are suggested.
Journal ArticleDOI
Endoplasmic reticulum stress and type 2 diabetes.
Sung Hoon Back,Randal J. Kaufman +1 more
TL;DR: This review examines how the UPR pathways, induced by high glucose and free fatty acids (FFAs), interact to disrupt ER function and cause β-cell dysfunction and death.