In the last decade, metal organic frameworks (MOFs) have shown great prospective as new drug delivery systems (DDSs) due to their unique properties: these materials exhibit fascinating architectures, surfaces, composition, and a rich chemistry of these compounds. The DSSs allow the release of the active pharmaceutical ingredient to accomplish a desired therapeutic response. Over the past few decades, there has been exponential growth of many new classes of coordination polymers, and MOFs have gained popularity over other identified systems due to their higher biocompatibility and versatile loading capabilities. This review presents and assesses the most recent research, findings, and challenges associated with the use of MOFs as DDSs. Among the most commonly used MOFs for investigated-purpose MOFs, coordination polymers and metal complexes based on synthetic and natural polymers, are well known. Specific attention is given to the stimuli- and multistimuli-responsive MOFs-based DDSs. Of great interest in the COVID-19 pandemic is the use of MOFs for combination therapy and multimodal systems.

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Applications of Metal-Organic Frameworks as Drug Delivery Systems

Carboxymethyl cellulose-coated HKUST-1 for baclofen drug delivery in vitro

Due to the fascinating molecular structure of MOFs and their widespread practical use in various industrial applications, great attention has focused on the development of commercialization techniques for up-scaled production...

K.H. Chae

Papers

Drug delivery of paracetamol by metal-organic frameworks (HKUST-1): improvised synthesis and investigations