K
K.S.R. Pai
Researcher at Manipal University
Publications - 59
Citations - 913
K.S.R. Pai is an academic researcher from Manipal University. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 16, co-authored 44 publications receiving 703 citations.
Papers
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Journal ArticleDOI
Synthesis and antitumor studies on novel Co(II), Ni(II) and Cu(II) metal complexes of bis(3-acetylcoumarin)thiocarbohydrazone
TL;DR: The compounds tested in present study have shown promising cytotoxic activity when screened using the in vitro method and at the same time were shown to have good activity when tested using the Ehrlich Ascites Carcinoma model.
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Vasorelaxant and antihypertensive effect of Cocos nucifera Linn. endocarp on isolated rat thoracic aorta and DOCA salt-induced hypertensive rats.
Girish R. Bankar,Pawan G. Nayak,Punit Bansal,Piya Paul,K.S.R. Pai,Rajeev K Singla,Varadaraj G Bhat +6 more
TL;DR: Findings reveal that the vasorelaxant and antihypertensive effects of CNE is due to direct activation of nitric oxide/guanylate cyclase pathway, stimulation of muscarinic receptors and/or via cyclooxygenase pathway.
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Evaluation of antioxidant and anticancer activity of extract and fractions of Nardostachys jatamansi DC in breast carcinoma
Shilpee Chaudhary,KS Chandrashekar,K.S.R. Pai,Manganahalli Manjunath Setty,Raviraj Anand Devkar,Neetinkumar D. Reddy,Muhammed Haneefa Shoja +6 more
TL;DR: The results suggest that NJM/fractions possess significant antiproliferative potential which is mediated through cell cycle perturbation and pro-apoptotic effects in MDA-MB-231 cells, and highlights the antioxidant potential of NJM-fractions which can be attributed to the presence of phenols.
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Synthesis, Structure, Electrochemistry, and Spectral Characterization of Bis-Isatin Thiocarbohydrazone Metal Complexes and Their Antitumor Activity Against Ehrlich Ascites Carcinoma in Swiss Albino Mice
TL;DR: The compounds synthesized in present study have shown promising cytotoxic activity when screened using the in vitro method and at the same time were shown to have good activity when tested using the Ehrlich ascites carcinoma model.
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Some new indole–coumarin hybrids; Synthesis, anticancer and Bcl-2 docking studies
TL;DR: Structural activity relationship of these hybrid molecules was studied to determine the effect of steric and electronic properties of the substituents on cell viability and compound 4c had a highly lipophilic bromine substituent capable of forming halogen bond.