K
Kai O. Lindros
Researcher at University of Pennsylvania
Publications - 2
Citations - 226
Kai O. Lindros is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Alcohol dehydrogenase & Acetaldehyde. The author has an hindex of 2, co-authored 2 publications receiving 226 citations.
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Journal ArticleDOI
Functional compartmentation of acetaldehyde oxidation in rat liver.
Roberto Parrilla,Kiyoshi Ohkawa,Kai O. Lindros,Un-Jin P. Zimmerman,Kumpei Kobayashi,John R. Williamson +5 more
TL;DR: It may be concluded that acetaldehyde generated during ethanol metabolism is oxidized to acetate predominantly in the mitochondria, so that only 1 eq of NADH is generated in the cytosol per mole of ethanol oxidized via alcohol dehydrogenase.
Journal ArticleDOI
Characteristics of Ethanol and Acetaldehyde Oxidation on Flavin and Pyridine Nucleotide Fluorescence Changes in Perfused Rat Liver
TL;DR: A comparison of pyridine nucleotide oxidation-reduction changes during ethanol infusion, and titrations with acetaldehyde in the absence and presence of 4-methylpyrazole (an inhibitor of alcohol dehydrogenase), showed that at lower acetaldehyde concentrations commensurate with those occurring during ethanol oxidation, the evidence indicates that acetaldehyde is normally oxidized in the mitochondrial compartment.