Kai Zhou

TL;DR: Applications of NGS in the clinical setting are described, such as outbreak management, molecular case finding, characterization and surveillance of pathogens, rapid identification of bacteria using the 16S-23S rRNA region, taxonomy, metagenomics approaches on clinical samples, and the determination of the transmission of zoonotic micro-organisms from animals to humans.

TL;DR: Distinct microbial communities, especially enriched Enterobacteriaceae, were associated with patients with AD when compared with predementia stage aMCI and healthy subjects, and a significant correlation was observed between the clinical severity scores of AD patients and the abundance of altered microbiomes.

TL;DR: Evidence demonstrating a role of TR variations in bacterial adaptation strategies, ranging from immune evasion and tissue tropism to the modulation of environmental stress tolerance, is reviewed.

TL;DR: A subclonal shift in the dominant clone sequence type (ST) 11 CRKP in which the previously prevalent capsular loci (KL) 47 had been replaced by KL64 since 2016 was detected, resulting in a significantly higher 30-day mortality rate and enhanced virulence in patients infected with ST11-KL64.

TL;DR: The study suggests the necessity for inter-institutional/regional collaboration for infection/outbreak management of K. pneumoniae HiRiCs and addresses the advantages of whole-genome sequencing in the early detection of HiR iC with a high propensity of nosocomial transmission and prolonged circulation in the regional patient population.