A
Alexander W. Friedrich
Researcher at University Medical Center Groningen
Publications - 345
Citations - 20121
Alexander W. Friedrich is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: Methicillin-resistant Staphylococcus aureus & Staphylococcal infections. The author has an hindex of 61, co-authored 335 publications receiving 16711 citations. Previous affiliations of Alexander W. Friedrich include Université libre de Bruxelles & University of Ulm.
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Journal ArticleDOI
Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis.
Evelina Tacconelli,Elena Carrara,Alessia Savoldi,Stéphan Juergen Harbarth,Marc Mendelson,Dominique L Monnet,Céline Pulcini,Gunnar Kahlmeter,Jan Kluytmans,Yehuda Carmeli,Marc Ouellette,Kevin Outterson,Jean B. Patel,Marco Cavaleri,Edward Cox,Christopher R. Houchens,M Lindsay Grayson,Paul Hansen,Nalini Singh,Ursula Theuretzbacher,Nicola Magrini,Aaron O. Aboderin,Seif Al-Abri,Nordiah Awang Jalil,Nur Benzonana,Sanjay Bhattacharya,Adrian Brink,Francesco Robert Burkert,Otto Cars,Giuseppe Cornaglia,Oliver J. Dyar,Alexander W. Friedrich,Ana Cristina Gales,Sumanth Gandra,Christian G. Giske,Debra A. Goff,Herman Goossens,Thomas Gottlieb,Manuel Guzman Blanco,Waleria Hryniewicz,Deepthi Kattula,Timothy Jinks,Souha S. Kanj,Lawrence Kerr,Marie-Paule Kieny,Yang Soo Kim,Roman S. Kozlov,Jaime Labarca,Ramanan Laxminarayan,Karin Leder,Leonard Leibovici,Gabriel Levy-Hara,Jasper Littman,Surbhi Malhotra-Kumar,Vikas Manchanda,Lorenzo Moja,Babacar Ndoye,Angelo Pan,David L. Paterson,Mical Paul,Haibo Qiu,Pilar Ramon-Pardo,Jesús Rodríguez-Baño,Maurizio Sanguinetti,Sharmila Sengupta,Mike Sharland,Massinissa Si-Mehand,Lynn L. Silver,Wonkeung Song,Martin Steinbakk,Jens Thomsen,Guy E. Thwaites,Jos W. M. van der Meer,Nguyen Van Kinh,Silvio Vega,Maria Virginia Villegas,Agnes Wechsler-Fördös,Heiman F. L. Wertheim,Evelyn Wesangula,Neil Woodford,Fidan O Yilmaz,Anna Zorzet +81 more
TL;DR: Future development strategies should focus on antibiotics that are active against multidrug-resistant tuberculosis and Gram-negative bacteria, and include antibiotic-resistant bacteria responsible for community-acquired infections.
Journal ArticleDOI
Escherichia coli Harboring Shiga Toxin 2 Gene Variants: Frequency and Association with Clinical Symptoms
Alexander W. Friedrich,Martina Bielaszewska,Wenlan Zhang,Matthias Pulz,Thorsten Kuczius,Andrea Ammon,Helge Karch +6 more
TL;DR: Stx2c-positive STEC isolates can cause HUS, but the presence of stx2d or stX2e may predict a milder disease with a minimal risk of HUS.
Journal ArticleDOI
The molecular evolution of methicillin-resistant Staphylococcus aureus.
Ruud H. Deurenberg,Cornelis Vink,Smilja Kalenić,Alexander W. Friedrich,Cathrien A. Bruggeman,Ellen E. Stobberingh +5 more
TL;DR: The epidemiology of MRSA has been investigated by pulsed-field gel electrophoresis (PFGE), multilocus sequence typing (MLST), spa typing and SCCmec typing, and the methods used to investigate the epidemiology and risk-factors associated with CA- MRSA and HA-MRSA are described.
Journal ArticleDOI
Methicillin-Resistant Staphylococcus aureus (MRSA): Burden of disease and control challenges in Europe
Robin Köck,Karsten Becker,Barry Cookson,J.E.W.C. van Gemert-Pijnen,Stéphan Juergen Harbarth,Jan Kluytmans,Martin Mielke,Georg Peters,Robert Skov,Marc Struelens,Marc Struelens,Evelina Tacconelli,A Navarro Torné,Wolfgang Witte,Alexander W. Friedrich +14 more
TL;DR: The current burden of MRSA infections in healthcare and community settings across Europe is described and the main threats caused by recent changes in the epidemiology of MR SA are outlined, aimed at identifying unmet needs of surveillance, prevention and control ofMRSA in Europe.
Journal ArticleDOI
Meticillin-resistant Staphylococcus aureus (MRSA): global epidemiology and harmonisation of typing methods
Stefania Stefani,Doo Ryeon Chung,Jodi A. Lindsay,Alexander W. Friedrich,Angela M. Kearns,Henrik Westh,Fiona M. MacKenzie +6 more
TL;DR: The group consensus was to recommend spa and staphylococcal cassette chromosome mec (SCCmec) typing as the preferred methods for MRSA, which are informative in defining particular strain characteristics and utilise standardised nomenclatures, making them applicable globally.