K
Kalju Kahn
Researcher at University of California, Santa Barbara
Publications - 25
Citations - 878
Kalju Kahn is an academic researcher from University of California, Santa Barbara. The author has contributed to research in topics: Urate oxidase & Hydrogen bond. The author has an hindex of 15, co-authored 25 publications receiving 844 citations. Previous affiliations of Kalju Kahn include University of California & University of Missouri.
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Journal ArticleDOI
Identification of the True Product of the Urate Oxidase Reaction
TL;DR: In this paper, the O2-dependent oxidation of urate catalyzed by urate oxidase has been examined in order to identify the immediate product of the enzymatic reaction Specifically labeled [13C]urates were utilized as substrates, and the time courses were monitored by 13C NMR.
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Parameterization of OPLS–AA force field for the conformational analysis of macrocyclic polyketides
Kalju Kahn,Thomas C. Bruice +1 more
TL;DR: The parameters for the OPLS–AA potential energy function have been extended to include some functional groups that are present in macrocyclic polyketides and it is proposed that the exact chemical makeup of the effector domain has little influence on the conformational preference of tetraketides.
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Spectroscopic characterization of intermediates in the urate oxidase reaction.
Kalju Kahn,Peter A. Tipton +1 more
TL;DR: The oxidation of urate catalyzed by soybean urate oxidase was studied under single-turnover conditions using stopped-flow absorbance and fluorescence spectrophotometry to show that the product of the reaction, 5-hydroxyisourate, is fluorescent, and its release from the active site occurred with a rate constant of 31 s-1.
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Kinetic mechanism and cofactor content of soybean root nodule urate oxidase.
Kalju Kahn,Peter A. Tipton +1 more
TL;DR: The kinetic mechanism of urate oxidase isolated from soybean root nodules has been determined by initial velocity kinetic studies monitoring oxygen uptake, and data suggest that there is no covalently bound cofactor in urate oxidation.
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Focal-point conformational analysis of ethanol, propanol, and isopropanol
Kalju Kahn,Thomas C. Bruice +1 more
TL;DR: Conformational analysis of three small alcohols was carried out by systematically improving the basis set and the level of electron correlation, raising a concern that the inability to accurately estimate this slowly converging contribution may become a limiting factor when highly accurate conformational energies in larger molecules are sought.