K
Kalpani K. Somarathne
Researcher at Victoria University of Wellington
Publications - 4
Citations - 24
Kalpani K. Somarathne is an academic researcher from Victoria University of Wellington. The author has contributed to research in topics: Lewis acids and bases & Cyclopropane. The author has an hindex of 2, co-authored 4 publications receiving 18 citations. Previous affiliations of Kalpani K. Somarathne include Victoria University, Australia.
Papers
More filters
Journal ArticleDOI
Reactions of 1,2-cyclopropyl carbohydrates
TL;DR: A review of 1,2-cyclopropyl car-bohydrates can be found in this article, where a wide variety of products are obtained depending on the functionality attached to the cyclopropane and the promoter (Lewis acid, Br o nsted acid, halophile or base).
Journal ArticleDOI
Synthesis of Bioactive Side-Chain Analogues of TAN-2483B.
Kalpani K. Somarathne,Jordan A. J. McCone,Amira Brackovic,José Luis Pinedo Rivera,J. Robin Fulton,Euan R. Russell,Jessica J. Field,Christopher L. Orme,Hedley L. Stirrat,Jasmin Riesterer,Paul H. Teesdale-Spittle,John H. Miller,Joanne E. Harvey +12 more
TL;DR: A chiral pool approach to this core and prepared side-chain analogues of TAN-2483B showed micromolar activity towards cancer cell lines HL-60, 1A9 and MCF-7 and certain human disease-relevant kinases, including Bruton's tyrosine kinase (Btk).
Journal ArticleDOI
Total Synthesis and Bioactivity Studies of Fungal Metabolite (-)-TAN-2483B.
Jordan A. J. McCone,Kalpani K. Somarathne,Christopher L. Orme,Russell J. Hewitt,Elysha-Rose Grant,Kelsi R. Hall,David F. Ackerley,Anne Camille La Flamme,Joanne E. Harvey +8 more
TL;DR: Inhibition of kinases Btk and Bmx, bacterial priority pathogens, and cytokine production in splenocytes indicates promising therapeutic potential and alkyne functionalization and carbonylation stereoselectively establish the bicyclic core of (-)-TAN-2483B.
Journal ArticleDOI
Reactions of 1,2-Cyclopropyl Carbohydrates
TL;DR: A review of 1,2-cyclopropyl car-bohydrates can be found in this paper, where a wide variety of products are obtained depending on the functionality attached to the cyclopropane and the promoter (Lewis acid, Br o nsted acid, halophile or base).