The 11th edition of Harrison's Principles of Internal Medicine welcomes Anthony Fauci to its editorial staff, in addition to more than 85 new contributors. While the organization of the book is similar to previous editions, major emphasis has been placed on disorders that affect multiple organ systems. Important advances in genetics, immunology, and oncology are emphasized. Many chapters of the book have been rewritten and describe major advances in internal medicine. Subjects that received only a paragraph or two of attention in previous editions are now covered in entire chapters. Among the chapters that have been extensively revised are the chapters on infections in the compromised host, on skin rashes in infections, on many of the viral infections, including cytomegalovirus and Epstein-Barr virus, on sexually transmitted diseases, on diabetes mellitus, on disorders of bone and mineral metabolism, and on lymphadenopathy and splenomegaly. The major revisions in these chapters and many

Harrison's Principles of Internal Medicine

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Principles Of Fluorescence Spectroscopy

Über die Adsorption in Lösungen

Positron Emission Tomography (PET) experienced accelerated development and has become an established method for medical research and clinical routine diagnostics on patient individualized basis. Development and availability of new radiopharmaceuticals specific for particular diseases is one of the driving forces of the expansion of clinical PET. The future development of the ⁶⁸Ga-radiopharmaceuticals must be put in the context of several aspects such as role of PET in nuclear medicine, unmet medical needs, identification of new biomarkers, targets and corresponding ligands, production and availability of ⁶⁸Ga, automation of the radiopharmaceutical production, progress of positron emission tomography technologies and image analysis methodologies for improved quantitation accuracy, PET radiopharmaceutical regulations as well as advances in radiopharmaceutical chemistry. The review presents the prospects of the ⁶⁸Ga-based radiopharmaceutical development on the basis of the current status of these aspects as well as wide range and variety of imaging agents.

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Prospective of ⁶⁸Ga-radiopharmaceutical development.

Gold nanoparticles (AuNPs) are a widespread research tool because of their oxidation resistance, biocompatibility and stability. Chemical methods for AuNP synthesis often produce toxic residues that raise environmental concern. On the other hand, the biological synthesis of AuNPs in viable microorganisms and their cell-free extracts is an environmentally friendly and low-cost process. In general, fungi tolerate higher metal concentrations than bacteria and secrete abundant extracellular redox proteins to reduce soluble metal ions to their insoluble form and eventually to nanocrystals. Fungi harbour untapped biological diversity and may provide novel metal reductases for metal detoxification and bioreduction. A thorough understanding of the biosynthetic mechanism of AuNPs in fungi is needed to reduce the time of biosynthesis and to scale up the AuNP production process. In this review, we describe the known mechanisms for AuNP biosynthesis in viable fungi and fungal protein extracts and discuss the most suitable bioreactors for industrial AuNP biosynthesis.

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Fungal biosynthesis of gold nanoparticles: mechanism and scale up

Encapsulation of Thymol in cyclodextrin nano-cavities: A multi spectroscopic and theoretical study.

Speciation and extraction of mercury has been studied using cloud point extraction of polyethylene glycol (PEG). A solution of PEG itself is reported to form cloud at a considerably high temperature which is unfavorable for the extraction and separation of volatile analytes. Different inorganic salt solutions (Na 2 SO 4 , NaH 2 PO 4 , NaCl, NaOAc) when used as additives were found to lower the cloud point temperature of PEG (#6000) effectively. The lowest temperature for cloud formation was observed at 35 °C with 0.8 M Na 2 SO 4 . The cloud so formed was found suitable to discriminate between inorganic and organic mercury species. 1-(2-pyridylazo)-2-napthol (PAN) was used for spectrophotometric detection of inorganic and organic mercury. Confocal microscopic images and zeta potential values reveal the actual interactions of the inorganic Hg species with the organized PEG micelles in aqueous medium. Environmental samples were also analyzed using the present method.

Kamalika Sen

Papers

Encapsulation of Thymol in cyclodextrin nano-cavities: A multi spectroscopic and theoretical study.

Discrimination for inorganic and organic mercury species by cloud point extraction of polyethylene glycol

Studies on stabilities of some human chorionic gonadotropin complexes with β-emitting radionuclides.

Peanut proteins: Applications, ailments and possible remediation

Ionic liquid vs tri-block copolymer in a new aqueous biphasic system for extraction of Zn-cholesterol complex