K
Kanoo Yamabe
Publications - 2
Citations - 105
Kanoo Yamabe is an academic researcher. The author has contributed to research in topics: Solubility & Dissolution testing. The author has an hindex of 2, co-authored 2 publications receiving 97 citations.
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Improvement of solubility and oral bioavailability of a poorly water‐soluble drug, TAS‐301, by its melt‐adsorption on a porous calcium silicate
Masahiro Kinoshita,Kazuhiko Baba,Atushi Nagayasu,Kanoo Yamabe,Takashi Shimooka,Yoh'ichiro Takeichi,Mami Azuma,Hitoshi Houchi,Kazuo Minakuchi +8 more
TL;DR: The present findings suggest melt-adsorption is a useful technique for improving solubility and bioavailability of poorly water-soluble drugs.
Journal ArticleDOI
Highly stabilized amorphous 3-bis(4-methoxyphenyl)methylene-2-indolinone (TAS-301) in melt-adsorbed products with silicate compounds.
Masahiro Kinoshita,Kazuhiko Baba,Atsushi Nagayasu,Kanoo Yamabe,Mami Azuma,Hitoshi Houchi,Kazuo Minakuchi +6 more
TL;DR: The results indicate the importance of optimizing the above factors in the preparation of melt-adsorbed product and indicate the stability of amorphous state of 3-Bis(4-Methoxyphenyl)methylene-2-indolinone is low in rats and dogs.