K
Kaori Ohtani
Researcher at University of Tsukuba
Publications - 16
Citations - 1538
Kaori Ohtani is an academic researcher from University of Tsukuba. The author has contributed to research in topics: Gene & Clostridium perfringens. The author has an hindex of 12, co-authored 16 publications receiving 1503 citations. Previous affiliations of Kaori Ohtani include Tokyo Medical University.
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Journal ArticleDOI
Complete genome sequence of Clostridium perfringens, an anaerobic flesh-eater
Tohru Shimizu,Kaori Ohtani,Hideki Hirakawa,Kenshiro Ohshima,Atsushi Yamashita,Tadayoshi Shiba,Naotake Ogasawara,Masahira Hattori,Satoru Kuhara,Hideo Hayashi +9 more
TL;DR: The genome analysis proved an efficient method for finding four members of the two-component VirR/VirS regulon that coordinately regulates the pathogenicity of C. perfringens, and a total of five hyaluronidase genes that will also contribute to virulence.
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The luxS gene is involved in cell-cell signalling for toxin production in Clostridium perfringens.
TL;DR: The results indicate that cell–cell signalling by AI‐2 plays an important role in the regulation of toxin production in C. perfringens.
Journal ArticleDOI
The virR/virS locus regulates the transcription of genes encoding extracellular toxin production in Clostridium perfringens.
William Ba-Thein,Michael Lyristis,Kaori Ohtani,IT Nisbet,Hideo Hayashi,Julian I. Rood,Tohru Shimizu +6 more
TL;DR: Either the virR/virS system modulates its effects via secondary regulatory genes that are specific for each toxin structural gene or the VirR protein does not have a single consensus binding sequence.
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Clostridial VirR/VirS regulon involves a regulatory RNA molecule for expression of toxins.
TL;DR: It was found that the small 3′‐portion of VR‐ RNA was sufficient for the activation of toxin genes, which suggested that VR‐RNA itself could act as an RNA regulatory molecule for the plc and colA genes mediating the regulatory information from the VirR/VirS system in C. perfringens.
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Staphylococcus aureus cell envelope antigen is a new candidate for the induction of IgA nephropathy
Akio Koyama,Samina Sharmin,Samina Sharmin,Hideko Sakurai,Hideko Sakurai,Yoshio Shimizu,Yoshio Shimizu,Kouichi Hirayama,Kouichi Hirayama,Joichi Usui,Joichi Usui,Michio Nagata,Michio Nagata,Keigyou Yoh,Keigyou Yoh,Kunihiro Yamagata,Kunihiro Yamagata,Kaori Muro,Kaori Muro,Masaki Kobayashi,Masaki Kobayashi,Kaori Ohtani,Kaori Ohtani,Takeshi Shimizu,Takeshi Shimizu,Tohru Shimizu,Tohru Shimizu +26 more
TL;DR: S. aureus cell envelope antigen is a new candidate for the induction of IgA nephropathy, and no deposition of this antigen was detected in the glomeruli of patients with non-immune complex deposit forms of glomerulonephritis.