T
Takeshi Shimizu
Researcher at University of Tsukuba
Publications - 73
Citations - 1464
Takeshi Shimizu is an academic researcher from University of Tsukuba. The author has contributed to research in topics: Metabolite & Medicine. The author has an hindex of 19, co-authored 67 publications receiving 1329 citations. Previous affiliations of Takeshi Shimizu include Tokyo Medical University & Hokkaido University.
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The virR gene, a member of a class of two-component response regulators, regulates the production of perfringolysin O, collagenase, and hemagglutinin in Clostridium perfringens.
TL;DR: A homology search for the deduced amino acid sequence revealed that ORF2 was homologous to a response regulator in a two-component signal transduction system, and it is suggested that the virR gene plays an important role in the pathogenicity of C. perfringens.
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Staphylococcus aureus cell envelope antigen is a new candidate for the induction of IgA nephropathy
Akio Koyama,Samina Sharmin,Samina Sharmin,Hideko Sakurai,Hideko Sakurai,Yoshio Shimizu,Yoshio Shimizu,Kouichi Hirayama,Kouichi Hirayama,Joichi Usui,Joichi Usui,Michio Nagata,Michio Nagata,Keigyou Yoh,Keigyou Yoh,Kunihiro Yamagata,Kunihiro Yamagata,Kaori Muro,Kaori Muro,Masaki Kobayashi,Masaki Kobayashi,Kaori Ohtani,Kaori Ohtani,Takeshi Shimizu,Takeshi Shimizu,Tohru Shimizu,Tohru Shimizu +26 more
TL;DR: S. aureus cell envelope antigen is a new candidate for the induction of IgA nephropathy, and no deposition of this antigen was detected in the glomeruli of patients with non-immune complex deposit forms of glomerulonephritis.
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Organic synthesis at high pressure
TL;DR: In this article, the authors recommend that all synthetic chemists should always consider pressure as one of the routine variables available to them, along with temperature, solvent, reaction time, catalysts, and so forth.
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Efficient method for preparation of N-methoxy-N-methyl amides by reaction of lactones or esters with Me2AlClMeONHMe·HCl
TL;DR: The reaction of a lactone or an ester with dimethylaluminum chloride and N, O -dimethylhydroxylamine hydrochloride provided an efficient method for preparation of N -methoxy- N -methyl amide as discussed by the authors.
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Morphobase, an Encyclopedic Cell Morphology Database, and Its Use for Drug Target Identification
Yushi Futamura,Makoto Kawatani,Sayaka Kazami,Kenichi Tanaka,Makoto Muroi,Takeshi Shimizu,Koji Tomita,Nobumoto Watanabe,Hiroyuki Osada +8 more
TL;DR: This study constructed a chemical-genetic phenotype profiling system, based on the high-content cell morphology database Morphobase, which demonstrates the applicability of this system in identifying NPD6689, NPD8617, and NPD8969 as tubulin inhibitors.